孟鲁司特钠辅助治疗慢性阻塞性肺气肿患者对炎症介质及肺功能的影响

Effects of Montelukast Sodium on Inflammatory Mediators and Pulmonary Function in Patients with Chronic Obstructive Pulmonary Emphysema

目的探讨孟鲁司特钠辅助治疗慢性阻塞性肺气肿(Chronic Obstructive pulmonary emphysema, COPE)患者对炎症介质及肺功能的影响。方法选取鞍山市千山医院2016年1月至2018年1月收治的112例COPE患者作为研究对象,随机分为两组,每组56例,对照组采用布地奈德雾化吸入治疗,观察组在对照组基础上加用孟鲁司特钠予以辅助治疗,比较两组患者治疗前后炎症介质和肺功能变化。结果治疗后,两组患者的白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)均显著下降,且观察组指标均显著低于对照组(P<0.05)。治疗后,两组患者用力肺活量(FVC)、第一秒钟用力呼气容积占用力肺活量比值(FEV1/FVC)和每分钟最大通气量(MVV)均明显高于治疗前,且观察组显著优于对照组,组间比较差异均有统计学意义(P<0.05)。结论采用孟鲁司特钠辅助治疗COPE患者可以有效降低炎症介质表达水平,改善肺功能。

Objective To investigate the effects of montelukast sodium on inflammatory mediators and pulmonary function in patients with chronic obstructive pulmonary emphysema(COPE).Methods A total of 112 COPE patients admitted to Anshan Qianshan Hospital from January 2016 to January 2018 were randomly divided into 2 groups,with 56 cases in each group.The control group was treated with Budesonide aerosol inhalation,while the observation group was treated with montelukast sodium on the basis of the control group.Inflammatory mediators and changes in lung function before and after treatment were compared between the 2 groups.Results After treatment,the levels of interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-alpha(TNF-alpha)in the 2 groups were significantly decreased,and the indexes in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the forced vital capacity(FVC),forced expiratory volume occupancy ratio(FEV1/FVC)and maximum ventilation volume per minute(MVV)of the 2 groups were significantly higher than those before treatment,and the observation group was significantly better than the control group,with significant differences between the 2 groups(P<0.05).Conclusion The use of montelukast sodium in the adjuvant treatment of COPE patients can effectively reduce the expression of inflammatory mediators and improve lung function.