左旋多巴联合恩他卡朋治疗帕金森病的临床疗效

Clinical Efficacy of Levodopa Combined with Entacapone in the Treatment of Parkinson’s Disease

目的探讨帕金森病患者应用左旋多巴联合恩他卡朋方案的临床疗效。方法选取大石桥市中心医院2015年1月至2018年1月收治的100例帕金森病患者作为研究对象,随机将其分为观察组与对照组,各50例。对照组采用左旋多巴治疗,观察组则采用左旋多巴联合恩他卡朋治疗。比较两组患者治疗效果、精神症状控制时间、语言行为改善时间、不良反应发生率以及治疗前后炎症介质指标、超氧化物歧化酶(SOD)、统一帕金森病评分量表-Ⅱ(UPDRS-Ⅱ)和统一帕金森病评分量表-Ⅲ(UPDRS-Ⅲ)评分。结果观察组治疗有效率高于对照组,差异有统计学意义(P<0.05);治疗后观察组炎症介质指标、SOD以及UPDRS-Ⅱ、UPDRS-Ⅲ评分变化幅度均优于对照组,差异有统计学意义(P<0.05);观察组精神症状控制时间、语言行为改善时间均优于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论左旋多巴联合恩他卡朋治疗帕金森病临床效果显著,可有效改善患者症状,减轻炎症反应和氧化应激反应,且用药安全较高。

Objective To explore the clinical efficacy of levodopa combined with entacapone in patients with Parkinson’s disease.Methods A total of 100 patients with Parkinson’s disease admitted to Dashiqiao Central Hospital from January 2017 to January 2018 were selected as the study subjects and randomly divided into observation group and control group,with 50 cases each.The control group was treated with levodopa,while the observation group was treated with levodopa combined with entacapone.The therapeutic effect,psychiatric symptom control time,speech behavior improvement time,adverse reaction rate,inflammatory mediators,superoxide dismutase,UPDRS-II and UPDRS-III were compared between the 2 groups before and after treatment.Results The effective rate of the observation group was higher than that of the control group(P<0.05);after treatment,the changes of inflammatory mediators,SOD,UPDRS-II and UPDRS-III scores in the observation group were better than those in the control group(P<0.05);the control time of psychiatric symptoms and the improvement time of language and behavior in the observation group were all better than those in the control group(P<0.05).Compared with the control group,the difference was statistically significant(P<0.05);there was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion Levodopa combined with entacapone has a significant clinical effects in the treatment of Parkinson’s disease.It can effectively improve the symptoms of patients,alleviate inflammation and oxidative stress,and is safe to use.