糖皮质激素辅助阿奇霉素治疗肺炎支原体大叶性肺炎患儿的疗效

Effects of Glucocorticoid-assisted Azithromycin in the Treatment of Mycoplasma Pneumoniae Lobar Pneumonia in Children

目的探讨糖皮质激素辅助阿奇霉素治疗肺炎支原体大叶性肺炎患儿的临床疗效。方法选取2018年6月至2019年5月于沈阳市妇婴医院病房及门诊治疗的肺炎支原体大叶性肺炎患儿100例作为研究对象,按随机数字表法分为观察组与对照组,每组50例。对照组给予阿奇霉素及对症治疗,观察组在此基础上采用小剂量糖皮质激素治疗,比较两组患儿症状改善时间、炎症介质、细胞免疫功能、肺功能及临床疗效。结果治疗后观察组症状改善时间、炎症介质水平、细胞免疫功能、肺功能及临床疗效均优于对照组,差异有统计学意义(P<0.05)。结论糖皮质激素辅助阿奇霉素治疗肺炎支原体大叶性肺炎效果显著,可有效减轻炎症反应,提高患儿免疫力,改善肺功能,促使其早日康复。

Objective To explore the clinical efficacy of glucocorticoid combined with azithromycin in the treatment of mycoplasma pneumoniae lobar pneumonia.Methods A total of 100 children with mycoplasma pneumoniae lobar pneumonia treated in wards and outpatient clinics of Shenyang Maternal and Infant Hospital from June 2018 to May 2019 were selected as the research objects.They were divided into observation group and control group according to random number table method,with 50 cases in each group.The control group was treated with azithromycin and symptomatic treatment,while the observation group was treated with low-dose glucocorticoid.The improvement time of symptoms,inflammatory mediators,cellular immune function,pulmonary function and clinical efficacy were compared between the 2 groups.Result After treatment,the improvement time of symptoms,levels of inflammatory mediators,cellular immune function,pulmonary function and clinical efficacy of the observation group were better than those of the control group,and the difference was statistically significant(P<0.05).Conclution Glucocorticoid-assisted azithromycin treatment of mycoplasma pneumoniae lobar pneumonia has a significant effect,can effectively reduce inflammation,improve the immune capacity of children,improve lung function,and promote their early recovery.