2型糖尿病采用胰岛素联合口服降糖药的临床疗效观察

Clinical Effect of Insulin Combined With Oral Hypoglycemic Drugs in the Treatment of Type 2 Diabetes

目的探究2型糖尿病患者采用胰岛素联合口服降糖药的临床治疗效果。方法选取江西省奉新县人民医院2012-10/2013-10门诊及住院54例2型糖尿病患者作为研究对象,按照治疗方法的不同将其分为实验组27例和对照组27例,实验组患者予以口服降糖药联合基础胰岛素治疗,对照组患者予以口服降糖药联合预混胰岛素治疗,观察两组患者治疗后的空腹血糖(FBG)、餐后2 h血糖(2h PBG)和糖化血红蛋白(Hb A1 C)水平以及两组患胰岛素剂量、低血糖发生率。结果治疗后空腹血糖实验组(5.1±0.4)mmol/L低于对照组(7.9±0.8)mmol/L、餐后2 h血糖实验组(8.1±2.2)mmol/L低于对照组(12.5±2.1)mmol/L、胰岛素使用剂量实验组(15.1±3.1)IU/d低于对照组(31.2±3.6)IU/d,治疗效果表明实验组均优于对照组,差异具有统计学意义(t=16.266 5,t=7.517 3,t=17.609 3;P值均<0.05)。结论在2型糖尿病患者治疗中,采用基础胰岛素联合口服降糖药治疗可对患者血糖实现良好控制,且胰岛素用量较少。

Objective To discuss the clinical effect of insulin combined with oral hypoglycemic drugs in treatment of type 2 diabetes. Methods Altogether 54 inpatients of type 2 diabetes were recruited during Oct.,2012 to Oct.,2013 in Fengxin County Hospital and divided into control group and experimental group,27 inpatients in each. The experimental group was given treatment insulin combined with oral hypoglycemic drugs and the control group was given oral hypoglycemic drugs and premixed insulin. The FBG,2h PBG and Hb A1 c,as well as the pancreatic insulin dose and the hypoglycemia incidence were observed and compared. Results The FBG after treatment in experimental group( 5. 1 ±0. 4) mmol / L was lower than that of control group( 7. 9 ± 0. 8) mmol / L( t = 16. 27,P < 0. 05); the blood glucose 2h after meal( 8. 1 ± 2. 2) mmol / L was lower than that of control group( 12. 5 ± 2. 1) mmol / L( t = 16. 266 5,t = 7. 517 3,P< 0. 05); the Insulin dosage of experimental group( 15. 1 ± 3. 1) IU / d was lower than that of control group( 31. 2 ±3. 6) IU / d( t = 17. 609 3,P < 0. 05). Conclusion In treating type 2 diabetes,basal insulin combined with oral hypoglycemic drugs can control can well control the blood glucose with a lower dosage.