加味二麻四仁汤联合穴位敷贴治疗气虚痰郁型支气管哮喘慢性持续期的临床观察

Clinical Observation of Modified Erma Siren Decoction Combined with Acupoint Application in Treatment of Bronchial Asthma with Qi Deficiency and Dampness Stagnation at Chronic Duration

目的:观察加味二麻四仁汤联合穴位敷贴治疗气虚痰郁型支气管哮喘慢性持续期的临床观察。方法:将符合纳入标准的95例气虚痰郁型支气管哮喘慢性持续期患者随机分为治疗Ⅰ组32例,治疗Ⅱ组32例和对照组31例。治疗Ⅰ组服用加味二麻四仁汤治疗,治疗Ⅱ组服用加味二麻四仁汤联合穴位敷贴治疗,对照组给予常规治疗,3组均连续治疗3个月。观察3组中医证候积分、临床疗效及肺功能的变化情况。结果:临床疗效方面,治疗Ⅰ组的总有效率81. 25%(26/32),治疗Ⅱ组的总有效率90. 62%(29/32),对照组的总有效率87. 10%(27/31),经秩和检验,治疗Ⅱ组的疗效最为显著,差异有统计学意义(P <0. 05)。治疗后3组中医证候积分均较前明显改善,差异有统计学意义(P <0. 05),治疗Ⅱ组与对照组及治疗Ⅰ组比较,改善更为明显,差异有统计学意义(P <0. 01)。治疗Ⅰ组与对照组相比,中医证候积分改善无统计学意义(P> 0. 05)。肺功能方面:3组患者治疗后肺功能FEV1均较治疗前明显改善,差异具有统计学意义(P <0. 05),治疗Ⅱ组FEV1的改善明显优于治疗Ⅰ组(P <0. 01),但与对照组相比FEV1的改善并无明显差异(P> 0. 05)。治疗Ⅰ组与对照组相比FEV1的改善也无明显差异(P> 0. 05)。3组患者治疗PEF均较前明显改善。差异具有统计学意义(P <0. 01),治疗Ⅱ组PEF的改善较对照组及治疗组更为明显(P <0. 05),治疗Ⅰ组PEF的改善与对照组相比,差异无统计学意义(P> 0. 05)。结论:加味二麻四仁汤联合穴位敷贴治疗气虚痰郁型支气管哮喘慢性持续期的临床疗效显著。

Objective: To observe the effect of modified Erma Siren Decoction combined with acupoint application in the treatment of bronchial asthma with qi deficiency and dampness stagnation at chronic duration.Methods: 95 patients of bronchial asthma with qi deficiency and dampness stagnation at chronic duration were randomly divided into the treatment group I(n = 32),the treatment group II(n = 32),and the control group(n = 31). The treatment group I was treated with modified Erma Siren Decoction;on which basis,the treatment group II was also treated with acupoint application. the control group was given conventional treatment.The three groups were treated continuously for three months. The changes of TCM syndrome scores,clinical efficacy and lung function were observed in the three groups. Results: The total effective rate was 81. 25%(26/32) in the treatment group I,it was 90. 62%(29/32) in the treatment group II,and it was 87. 10%(27/31) in the control group;of which the treatment group II had the highest curative effect rate(P < 0. 05).The scores of TCM syndromes were significantly improved after the treatment in the three groups(P < 0. 05);of which the improvement was most significant in the treatment group II(P < 0. 01);there was no statistical difference in the improvement of TCM syndrome between the treatment group I and the control group(P >0. 05). The FEV1 was significantly improved after the treatment compared to that before the treatment in the three groups(P < 0. 05);the improvement of FEV1 was more significant in the treatment group II compared to that in the treatment group I(P < 0. 01);there was no statistical difference in the improvement of FEV1 between the treatment group II and the control group(P > 0. 05),as well as between the treatment group I and the control group(P > 0. 05). The PEF was significantly improved after the treatment in the three groups(P <0. 01);the improvement of PEF was more significant in the treatment group II than that in the treatment group I and the control group(P < 0. 05);however,there was no statistical difference in PEF improvement between the treatment group I and the control group(P > 0. 05). Conclusion: Modified Erma Siren Decoction combined with acupoint application is effective in treating bronchial asthma with qi deficiency and dampness stagnation at chronic duration.