染色体多态性与女性不良妊娠结局关系探讨

Relationship between chromosomal polymorphism and female adverse pregnancy outcome

目的探讨染色体多态性与女性不良妊娠结局的相关性。方法对2015年1月-2018年6月在我院就诊的1684例有流产、死胎和胚胎停育等不良妊娠结局的女性遗传咨询者的进行细胞遗传学检查,分析染色体多态性的发生率和构成情况。结果在1684例不良妊娠结局的女性遗传咨询者中检出染色体多态性核型46例,发生率2.73%,主要包括(1)1号和9号染色体次缢痕增加共12例,构成比26.09%;(2)D/G组13号、14号和15号染色体随体增加共14例,构成比30.43%;(3)9号染色体臂间倒位共20例,构成比43.48%。在812例女性自然流产遗传咨询者中检出染色体多态性核型32例,发生率3.94%;在624例女性复发性流产遗传咨询者中检出染色体多态性核型18例,占发生率2.88%;在262例畸胎史女性遗传咨询者中检出染色体多态性核型22例,发生率8.40%;在276例胚胎停育女性遗传咨询者中检出染色体多态性核型14例,发生率5.07%。结论染色体多态性与女性不良妊娠密切相关,是导致女性不良妊娠的重要因素。

Objective:To investigate the relationship between chromosomal polymorphism and female adverse pregnancy outcomes.Methods:A total of 1684 female genetic counselors who had abortion,stillbirth and embryonic stoppages in our hospital from January to May 20,2015 were enrolled in the cytogenetic examination to analyze the incidence of chromosomal polymorphism.And the composition of the situation.Results:A total of 46 karyotypes were detected in 1684 female genetic counselors with adverse pregnancy outcomes,with an incidence of 2.73%,including(1)a total of 12 cases of chromosome 1 and9 scars.26.09%;(2)D/G group 13 th,14 th and 15 th chromosomes increased by 14 cases,the proportion of 30.43%;(3)20 cases of chromosome 9 inversion between the total of 20 cases,the composition ratio of 43.48%.In 812 female spontaneous abortion genetic counselors,32 cases of chromosomal polymorphism were detected,the incidence rate was 3.94%;18 cases of chromosomal polymorphisms were detected in 624 female recurrent abortion genetic counselors,accounting for the occurrence The rate was 2.88%;22 cases of chromosomal polymorphisms were detected in 262 female genetic counselors with a history of 8.40%;chromosomal polymorphisms were detected in 276 female genetically inseminated women.14 cases,the incidence rate was 5.07%.Conclusion:Chromosome polymorphism is closely related to women’s adverse pregnancy and is an important factor leading to women’s adverse pregnancy.