摘要
服用具有益气养阴活血作用的气血通降低大鼠衰老死亡率(12/24,对照组33/44,P<0.05),抑制其心肌脂质过氧化物丙二醛的增加(65±3,对照组88±5nmol/g w.w,P<0.01)。在离体成年大鼠心肌细胞模型上,气血通拮抗自由基发生系统(FeCl_2和抗坏血酸)的细胞损伤作用,增加细胞存活率和减少细胞乳酸脱氢酶漏出,抑制细胞丙二醛含量的增加。气血通的这些作用呈剂量依赖关系。本工作提示气血通抗脂质过氧化的心肌细胞保护作用,可能是其抗衰老的重要机制之一。
Administration of "Qi Xue Tong" , which has the effects of reinforcement of Qi, replenishment of Yin and activation of the blood, decreased the rat ageing mortality (12/24, vs. 33/44 of control group, p<0.05) and inhibited the increase of the lipid peroxidation product, MDA, in aged rat myocardium (65±3 vs. 88±5nmol/g ww, p<0.01). On the isolated adult rat ventricular myocytes, "Qi Xue Tong" alleviated cell damage induced by free radical generating system (FeCh and ascorbic acid) , and increased the cell viability and decreased the leakage of intracellular lactate dehydroge-nase, and inhibited the increase in cell MDA content. These effects of "Qi Xue Tong" are dose-dependent. The results showed that the protective effect of "Qi Xue Tong" on the myocardial cells from lipid peroxidation is one of the important mechanisms against ageing.
出处
《中药药理与临床》
CAS
1988年第4期10-12,共3页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家科委自然科学基金
