阿魏酸钠的药代动力学研究

Study on Pharmacokinetics of Sodium Ferulate

本文对文献中用高效液相色谱法测定血浆阿魏酸浓度的方法作了改进,并用此法对阿魏酸在兔体内的药代动力学进行了研究。结果表明,阿魏酸钠在兔的体内过程属于开放式一室模型,灌胃后吸收迅速。

A HPLC method for determination of ferulic acid in plasma andapplication of this method in pharmacokinetic study in rabbits have been described. The ferulic acid was extracted from acidified plasma with ether. Zorbax-NH2 column and methanol-0.14N acetic acid (60:40, v/v)as mobile phase were used. The detection wa-velengti was 330am. The assay linearity is ranging from 0.1-10.0μg/ml plasma with a regression coefficient of 0.999.Studies on pharmacokinetics after ig sodium ferulate in rabbits have shown that its process belongs to open one compartment model. The parameters were shown in Tab. 3. The absorption of sodium ferulate was fast after ig. administration in rabbits.