艾迪注射液联合化疗治疗晚期食管癌的临床观察

Clinical study of Aidi Injection combined with chemotherapy in treatment of advanced esophageal cancer

目的:观察艾迪注射液联合顺铂与氟尿嘧啶治疗晚期食管癌的临床疗效。方法:将46例晚期食管癌患者随机分为观察组(24例)和对照组(22例),观察组给予顺铂、氟尿嘧啶,同时给予艾迪注射液;对照组单纯化疗,方案同观察组。结果:观察组和对照组近期疗效有效率分别为41.6%和40.9%,无显著性差异(P>0.05);但观察组临床症状改善率和KPS评分提高率显著高于对照组,观察组II度以上白细胞和血小板减少的发生率显著低于对照组。结论:艾迪注射液可以改善晚期食管癌患者的临床症状,减轻化疗的不良反应,提高患者的生活质量。

Objective to observe the therapeutic efficacy of Aidi injection combined with cisplation and 5-fluorouracil(PF regimen)chemotherapy in treatment of advanced esophageal cancer.Methods 46 cases of advanced esophageal cancer were divided randomly into two groups.24 patients of test group were treated with Aidi injection(50 ml,d1 ~ d14) combined with cisplation(DDP 30 mg/m2,d1 ~ d3)and 5-fluorouracil(5-Fu 500 mg/m2,d1 ~ d5).22 patients of control group only received PF chemotherapy.The therapeutic efficacy of the two groups was evaluated after two cycles of treatment.Results The overall response rates of test group and control group were 41.6% and40.9%,there was no statistically significant difference(P>0.05).The symptoms control rate of test group was higher than that of control group(P<0.05).The life quality of patients in test group was superior to the patients in control group(P<0.05).II ~ IV degree myelosuppression rate of test group was lower than that of control group(P<0.05).Conclusion Aidi injection has the function of alleviating the symptoms and poisonous side-effect of chemotherapy medicine and improving life quality of patients with advanced esophageal cancer.