基于"久病及肾"理论论治扶正抑癌1号方联合GP化疗治疗晚期非小细胞肺癌的临床观察

Clinical observation on the treatment of late stage non-small cell lung cancer by GP chemotherapy combined with Fuzhengyiai prescription No.1 based on Jiubingjishen theory

目的:基于'久病及肾'理论,观察扶正抑癌1号方联合GP化疗与单纯化疗对比治疗晚期非小细胞肺癌的临床疗效、安全性及对患者生活质量的影响。方法:选取2017年9月1日至2018年9月1日于成都中医药大学附属医院及四川省肿瘤医院就诊的晚期非小细胞肺癌患者86例,随机分为两组,试验组46例,对照组40例,对照组给予GP方案化疗,试验组在对照组基础上联合中药扶正抑癌1号方治疗,4周期后,比较两组实体瘤目标病灶疗效、中医临床证候疗效、生活质量及毒副反应。结果:试验组实体瘤目标病灶总有效率有大于对照组的趋势;而在生活质量及中医临床证候疗效方面,试验组均优于对照组,化疗毒副作用的发生率明显低于对照组。结论:基于'久病及肾',以扶正抑癌1号方联合GP化疗治疗晚期非小细胞肺癌,在客观疗效上与单纯GP方案化疗相比可能相当,但可提高患者生活质量,减少化疗毒副作用的发生。

Objective:Based on Jiubingjishen theory,we compared the clinical efficacy,safety and the quality of life of patients with late stage non-small cell lung cancer(NSCLC)after the treatment by GP chemotherapy and GP chemotherapy combined with Fuzhengyiai prescription No.1,respectively.Methods:86 patients with late stage non-small cell lung cancer from Hospital of Chengdu University of Traditional Chinese Medicine and Sichuan provincial tumor hospital from September 1,2017 to September 1,2018.All patients were randomly divided into two groups,46 in the treatment group and 40 in the control group.Patients in the control group were given GP chemotherapy,while those in the treatment group were treated with Fuzhengyiai prescription No.1 combined with GP chemotherapy.After 4 cycles of the treatment,the solid tumor target lesion curative effect,TCM clinical syndrome effect,quality of life and toxic side effects in these two groups were compared.Results:Compared with the control group,the total effective rate of the target lesion of solid tumor was increased in the treatment group,but there was no statistically significant difference.Life quality and TCM clinical syndrome in the treatment group showed better effects than those in the control group,also it showed less side or toxic effects of chemotherapy in the treatment group than that in the control group.Conclusion:Based on Jiubingjishen theory,Fuzhengyiai prescription No.1 combined with GP chemotherapy for the treatment of late stage non-small cell lung cancer may have similar efficacy as GP chemotherapy applied alone,but it can improve the quality of patients life and reduce the occurrence of toxic or side effects of chemotherapy.