妇科活血止痛颗粒药物的抗炎实验研究

Experimental Study on Antiinflammatory Effect of Huoxuezhitong Granules for Gynaecological Diseases

目的 :研究妇科活血止痛颗粒的抗炎情况。方法 :小鼠耳肿胀模型、小鼠毛细血管通透性模型各70只昆明种小鼠,均随机分为7组,即空白对照组、阳性组、给药组5组(剂量分别为0.082,0.164,0.328,0.656,1.312 g/kg),每组10只,灌胃给药,1天1次,连续七天,通过小鼠耳肿胀模型、小鼠毛细血管通透性模型,观察妇科活血止痛颗粒的抗炎作用。结果:与对照组相比,供试品剂量为0.082,0.164,0.328,0.656g/kg时均可减轻二甲苯致小鼠耳肿胀(P<0.05),供试品剂量为1.312 g/kg时统计学具有非常显著性差异(P<0.01);供试品剂量为1.312 g/kg时能显著降低大鼠毛细血管通透性(P<0.05)。结论 :妇科活血止痛颗粒具有较强的抗炎作用。

Objective:To investigate the anti-inflammatory effect of huoxuezhitong granules for gynecological diseases. Methods:Mice ear-swelling models and capillary permeability models were randomnized into 7 groups with each group 10 Kunming mice, respectively, either of which included blank control, positive control and five test groups. The dosages for five test groups were 0.082, 0.164, 0.328, 0.656 and 1.312 g/kg respectively. The ten mice in each group were administered by lavage, once a day for 7 d, and obseved for the anti-inflammatory effect of fuke huoxue zhitong granules. Resuts:Compared with those in control group, the test samples at dosages of 0.082, 0.164, 0.328 and 0.656 g/kg relieved the ear swelling of mice caused by dimethylbenzene(P<0.05), while that at a dosage of 1.312 g/kg relieved significantly(P<0.01). The test samples at a dosage of 1.312 g/kg significantly decreased the permeability of rat capillary vessel(P<0.05). Conclusion:Huoxuezhitong granules for gynecological disease showed strong anti-inflammatory effect.