氨氯地平联合缬沙坦治疗原发性高血压的疗效及对颈动脉硬化病变的逆转作用分析

Curative Effect of Amlodipine Combined with Valsartan on Primary Hypertension and Arteriosclerosis Disease

目的 :分析缬沙坦联合氨氯地平治疗原发性高血压的疗效及对颈动脉硬化病变的逆转效果。方法:将80例原发性高血压患者按照随机数字表法分为氨氯地平组和缬沙坦组,各40例;氨氯地平组给予氨氯地平片治疗,缬沙坦组给予缬沙坦胶囊和氨氯地平片治疗;治疗24周后,比较两组患者的血脂代谢、24 h动态血压及颈动脉超声检查结果。结果 :治疗后,缬沙坦组患者的24 h平均动脉压(24 h MAP)、24 h舒张压(24 h DBP)和24 h收缩压(24 h SBP)均显著低于氨氯地平组(P<0.05);缬沙坦组高密度脂蛋白胆固醇(HDL-C)明显高于氨氯地平组,低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)和总胆固醇(TC)明显低于氨氯地平组(P<0.05);缬沙坦组患者的斑块长径、斑块厚度和颈动脉内膜厚度(IMT)均明显低于氨氯地平组(P<0.05)。结论 :缬沙坦联合氨氯地平显著提高原发性高血压患者降压效果和颈动脉硬化病变逆转效果,且改善患者的血脂代谢,值得临床重视。

Objective:To analyze the curative effect of amlodipine combined with valsartan on primary hypertension and arteriosclerosis disease. Methods:A total of 80 patients with primary hypertension were randomly divided into amlodipine and valsartan groups, 40 for each. The patients in amlodipine group were treated with amlodipine tablets, while those in valsartan group with valsartan capsules and amlodipine tablets. for 24 weeks. The blood lipid metabolism, 24 h ambulatory blood pressure and carotid artery ultrasound examination results in the two groups were compared. Results:After treatment, the 24 h mean arterial pressure(MAP), 24 h diastolic blood pressure(DBP) and 24 h systolic blood pressure(SBP) in valsartan group were significantly lower, while the HDL-C was significantly higher, and LDL-C, TG and TC were significantly lower than those in amlodipine group(each P<0.05). However, the length and diameter of plaque, plaque thickness and carotid intima-media thickness(IMT) in valsartan group were significantly lower than those in amlodipine group(P<0.05). Conclusion:Valsartan combined with amlodipine significantly enhanced the anti-hypertension and reverse of carotid atherosclerosis in patients with primary hypertension, and improved the blood lipid metabolism, which was worthy of being paid attention in clinic.