顺铂联合博来霉素术前介入化疗治疗宫颈癌的临床疗效及对血清DcR3、Survivin的影响

Curative Effect of Interventional Chemotherapy by Cisplatin Combined with Bleomycin before Surgery on Cervical Carcinoma and Its Influence on Serum DcR3 and Survivin

目的 :研究顺铂联合博来霉素术前介入化疗治疗宫颈癌的临床疗效及对血清DcR3、Survivin的影响。方法:选取2015年1月-2016年6月郑州市妇幼保健院70例宫颈癌子宫全切手术的患者为研究对象,按随机数字表法分成A、B两组,每组35例。A组采用顺铂(70 mg/m^2)联合博来霉素(30 mg)术前介入化疗,B组术前不采用任何治疗,14天后A、B两组均行广泛子宫切除术+盆腔淋巴结清扫术。分别于治疗前及术后1个月对患者进行影像学检查及肿瘤标志物检查明确疗效,并检测患者血清DcR3、Survivin的水平变化。结果:A组的总缓解率为82.86%,高于B组总缓解率71.43%,但两者差异并无统计学意义(P>0.05)。A、B两组患者在治疗前诱骗受体3(DcR3)与生存素(Survivin)水平均无明显差异(P>0.05)。治疗后,两组患者DcR3与Survivin水平均较治疗前明显下降,差异有统计学意义(P<0.05),治疗后A组DcR3与Survivin水平明显低于B组,差异有统计学意义(P<0.05)。结论 :顺铂联合博来霉素术前介入化疗可以有效降低宫颈癌患者的血清DcR3、Survivin水平,其临床效果值得肯定。

Objective:To investigate the curative effect of interventional chemotherapy by cisplatin combined with bleomycin before surgery on cervical carcinoma as well as its influence on DcR3 and Survivin in sera.Methods:A total of 70 patients with cervical carcinoma receiving total hysterectomy in Zhengzhou Maternal and Child Health Care Hospital from January 2015 to June 2016 were randomly divided into groups A and B,35 for each.The patients in group A received interventional chemotherapy by cisplatin(70 mg/m^2)combined with bleomycin(30 mg),while those in group B received no therapy before surgery.The patients in both groups A and B received extensive hysterectomy+pelvic lymph node dissection 14 d later.The patients were subjected to imaging examination and test for tumor markers before therapy and one month after surgery,of whom the DcR3 and Survivin levels in sera were determined.Results:The total remission rate in group A was 82.86%,which was insignificantly higher than that in group B(71.43%)(P>0.05).The DcR3 and Survivin levels in two groups showed no significant differnce before therapy(P>0.05),while decreased significantly after therapy(P<0.05).However,the DcR3 and Survivin levels in group A after therapy were significanly lower than those in group B(P<0.05).Conclusion:The interventional chemotherapy by cisplatin combined with bleomycin before surgery effectively decreased the serum DcR3 and Survivin levels of patients with cervical carcinoma,indicating a definitely curative effect.