右美托咪定联合舒芬太尼在骨科手术术后镇痛中的应用效果研究

Application of Dexmedetomidine Combined with Sulfentanyl in Analgesia after Orthopedic Surgery

目的:探讨右美托咪定联合舒芬太尼在骨科手术术后镇痛中的临床效果。方法:选取2015年8月-2016年8月在我院骨科手术患者60例。按照随机数字表法分为观察组和对照组,对照组术后给予单纯舒芬太尼[0.05μg/(kg·h)]镇痛,观察组则在舒芬太尼[0.05μg/(kg·h)]治疗的基础上联合右美托咪定[0.05μg/(kg·h)]进行镇痛,对两组患者手术后的4,12,48 h疼痛、镇静程度进行评分,记录不良反应并对不良反应发生率进行比较。结果:观察组4,12,48 h疼痛评分低于对照组低,差异有统计学意义(P<0.05)。观察组4,12,48 h镇静评分高于对照组,差异有统计学意义(P<0.05)。观察组的不良反应发生率较对照组低,差异有统计学的意义(P<0.05)。结论 :在舒芬太尼治疗的基础上,联合右美托咪定进行镇痛,能够提高镇痛效果,不良反应发生少,值得临床推广使用。

Objective:To investigate the role of dexmedetomidine combined with sulfentanyl in analgesia after orthopedics surgery.Methods:A total of 60 patients receiving orthopedic surgery in Luoyang Bonesetting Hospital of Henan Province/Henan Provincial Hospital of Orthopaedics from August 2015 to August 2016 were randomly divided into trial and control groups.The patients in control group were treated with sulfentanyl for analgesia after surgery,while those in trial groups with dexmedetomidine[0.05μg/(kg·h)]combined with sulfentanyl(0.05μg/(kg·h))The pains and calmnesses in two groups 4,12 and 48 h after surgery were scored,while the adverse reactions were recorded,and the incidences the reactions were compared.Results:The scores for pain in trial group 4,12 and 48 h after surgery were significantly lower,while those for calmness were significantly higher,than those in control group(P<0.05).However,the incidence rate of adverse reactions in trial group was significantly lower than that in control group(P<0.05).Conclusion:Dexmedetomidine combined with sulfentanyl enhanced the effect of analgesia and decreased the adverse reactions,which was worthy of popularization in clinic.