阿奇霉素序贯疗法治疗小儿支原体肺炎的疗效观察

Clinical Observation of Azithromycin Sequential Therapy in the Treatment of Children with Mycoplasma Pneumonia

目的 :观察阿奇霉素序贯疗法治疗小儿支原体肺炎的临床治疗效果及其安全性分析。方法 :选取2014年4月-2017年3月在我院儿科住院治疗的82例支原体肺炎患儿作为研究对象,按治疗药物不同分为甲、乙两组,各41例。甲组采用阿奇霉素序贯疗法[10 mg/(kg·d)],乙组给予红霉素[20~30 mg/(kg·d)]进行治疗,观察两组患儿临床治疗效果及不良反应发生情况。结果 :甲组治疗总有效率为100%高于乙组的90.48%,乙组不良反应发生率为38.10%高于甲组的9.52%,差异均有统计学意义(P<0.05)。结论 :阿奇霉素序贯疗法治疗小儿支原体肺炎临床疗效显著,不良反应少,值的临床推广使用。

Objective:To observe the clinical efficacy and safety of azithromycin sequential therapy in the treatment of children with mycoplasma pneumonia. Methods:82 cases of children with mycoplasma pneumonia from April 2014 to March 2017 in pediatric department of our hospital were chosen as the research object. The patients were divided into two groups according to different treatment, 41 cases in each group. The group A was given azithromycin sequential therapy[10 mg/(kg·d)] and the group B was given erythromycin[20~30 mg/(kg·d)], the clinical therapeutic effects and the rate of adverse reactions were observed of two groups. Results:The total effective rate of group A(100%) was higher than group B(90.48%), the rate of adverse reactions of group A(9.52%) was lower than group B(38.10%), the differences were statistically significant(P<0.05). Conclusion:Azithromycin sequential therapy in the treatment of children with mycoplasma pneumonia can obtain better clinical curative effect and less adverse reactions. It is worthy of clinical application..