米非司酮联合米索前列醇配合无痛清宫术治疗稽留流产的效果观察

Effect Observation of Mifepristone and Misoprostol Combined with Painless Curettage in the Treatment of Missed Abortion

目的 :探讨米非司酮联合米索前列醇配合无痛清宫术治疗稽留流产的效果。方法 :选择2015年1月-2017年1月在我院治疗的稽留流产患者234例为研究对象,按随机数字表法分为对照组与研究组,各117例。对照组给予戊酸雌二醇片(2 mg,tid)联合无痛清宫术治疗,研究组给予米非司酮(100 mg,qd)配伍米索前列醇(600μg,qd)联合无痛清宫术治疗。观察两组宫颈扩张效果、手术时间、术中出血量、妊娠物排出时间、丙泊酚用量、1次清宫成功率。结果 :研究组手术时间、术中出血量、妊娠物排出时间、丙泊酚用量均显著低于对照组(P<0.05),1次清宫成功率显著高于对照组(P<0.05)。研究组宫颈扩张有效率显著高于对照组(P<0.05)。结论:米非司酮联合米索前列醇配合无痛清宫术治疗稽留流产具有明显优势,值得推广应用。

Objective:To investigate the effect of mifepristone and misoprostol combined with painless curettage in the treatment of missed abortion. Methods:234 cases of missed abortion were selected from January 2015 to January 2017 in our hospital as the research object, and the patients were randomly divided into control group and study group, 117 cases in each group. Control group was given estradiol valerate tablets(2 mg, tid) combined with painless curettage, study group was given mifepristone(100 mg, qd) and misoprostol(600 μg, qd) combined with painless curettage. The effect of cervix dilatation, operation time, intraoperative bleeding volume, the efflux time of pregnancy thing, dosage of propofol and the success rate of curettage in 1 time were observed. Results:The operation time, intraoperative bleeding volume, the efflux time of pregnancy thing and the dosage of propofol were significantly lower than those of control group(P<0.05), the success rate of curettage in 1 time was significantly higher than that of the control group(P<0.05). The effective rate of cervical dilatation of study group was significantly higher than that of the control group(P<0.05). Conclusion:Mifepristone and misoprostol combined with painless curettage in the treatment of missed abortion has obvious advantages, it is worthy of popularization and application.