腺苷蛋氨酸联合门冬氨酸钾镁治疗小儿重度黄疸性肝炎的临床疗效

Clinical Efficacy of Potassium Magnesium Aspartate Combined with Adenosyl Methionine in the Treatment of Children with Severe Icterohepatitis

目的 :探讨腺苷蛋氨酸联合门冬氨酸钾镁治疗小儿重度黄疸性肝炎的临床疗效。方法 :按随机数字表法将135例小儿重度黄疸性肝炎患儿分为两组,对照组68例以门冬氨酸钾镁(20~30 m L,qd)联合促肝细胞生长素(120 mg,qd)治疗,观察组67例在对照组基础上静脉滴注腺苷蛋氨酸(500 mg^1 g,qd),治疗2个疗程后比较临床疗效。结果 :观察组临床疗效明显优于对照组(P<0.05)。两组患儿治疗后血清总胆红素(TB)、结合胆红素(DB)、丙氨酸氨基转移酶(ALT)、总胆汁酸(TBA)、凝血酶原时间(PT)水平降低,白蛋白(ALB)水平升高,观察组治疗后血清TB、DB、ALT、TBA、PT水平低于对照组,血清ALB水平高于对照组(P<0.05)。结论 :小儿重度黄疸性肝炎患儿采用腺苷蛋氨酸联合门冬氨酸钾镁治疗,能明显改善患儿肝功能,提高临床疗效。

Objective:To explore the clinical efficacy of adenosyl methionine combined with potassium magnesium aspartate in the treatment of children with severe icterohepatitis. Methods:135 children with severe icterohepatitis were divided into two groups according to the random number table method. The control group(68 cases) were treated with potassium magnesium aspartate(20~30 m L,qd) combined with promoting hepatocyte growth factor(120 mg,qd), the observation group(67 cases) was treated with potassium magnesium aspartate(20~30 m L, qd) based on the control group. The clinical efficacy was compared after 2 courses of treatment. Results:The clinical curative effect of the observation group was better than that of the control group(P<0.05). After treatment, the serum total bilirubin(TB), direct bilirubin(DB), alanine aminotransferase(ALT), total bile acid( TBA) and prothrombin time(PT) of two groups were lower than those of before treatment, the serum albumin(ALB) was higher than that before treatment. After treatment, TB, DB, ALT, TBA and PT of observation group were lower than those of control group, the serum ALB was higher than that of control group(P<0.05). Conclusion:Adenosyl methionine combined with potassium magnesium aspartate in the treatment of children with severe icterohepatitis can effectively improve the liver function, and can improve the therapeutic effect.