阿奇霉素联合异烟肼等抗结核药物治疗妊娠肺结核的疗效观察

Efficacy of Azithromycin Combined with Isoniazid and Other Antituberculosis Drugs in the Treatment of Tuberculosis During Pregnancy

目的:观察阿奇霉素联合异烟肼等抗结核药物治疗妊娠期肺结核的疗效及安全性。方法:将58例初诊的妊娠肺结核患者根据治疗方式不同分为观察组31例和对照组27例,对照组采用传统抗结核药物(异烟肼0.3 g,乙胺丁醇0.75 g,利福平0.45 g,顿服)治疗,观察组采用口服阿奇霉素(0.5 g,qd,3个月后改为0.5 g,qod)联合传统抗结核药物治疗,观察并比较两组患者在治疗效果、妊娠结局、不良反应方面的差异。结果:两组妊娠结局比较无统计学差异(P>0.05)。观察组治疗总有效率为82.75%,高于对照组的75.00%(P<0.05);两组药物不良反应差异无统计学意义(P>0.05)。结论 :阿奇霉素联合传统抗结核药物治疗妊娠肺结核可促进痰菌转阴,病灶吸收,母婴安全性良好。

Objective:To examine the efficacy and safety of azithromycin combined with isoniazid and other anti-tuberculosis drugs in the treatment of tuberculosis(TB) during pregnancy.Methods:Fifty-eight newly diagnosed pregnant TB patients were randomly divided into the control group(n=27) and treatment group(n=31).Patients in the control group were given traditional anti-TB drug therapy(0.3 g isoniazid,0.75 g ethambutol and 0.45 g rifampicin,taken at a drought),and treatment group patients were given oral azithromycin(0.5 g qd,after 3 months,changed to 0.5 g,qod) combined with traditional anti-TB drug therapy.Treatment efficacy,pregnancy outcomes and adverse reactions were compared between the two groups.Results:There were no significant differences in pregnancy outcome and adverse drug reactions between the two groups of patients(both P>0.05).Total effective rate of treatment was significantly higher in the treatment group than in the control group(82.75% vs.75.00%,P<0.05).Conclusion:Azithromycin combined with traditional anti-TB drug treatment can enhance sputum bacteria removal and TB lesion absorption,and is a safe treatment for both the baby and mother.