替加环素在重症患者经验性抗感染治疗中的临床疗效

Clinical Efficiency of Tigecycline in Empirical Anti-infection of Critical Patients

目的:探讨替加环素在重症患者经验性抗感染治疗中的临床疗效。方法:选取2016年3月-2017年3月我院ICU予以替加环素治疗的100例重症患者为研究对象,记录分离株菌的培养结果,比较患者治疗前后白细胞和降钙素原水平,序贯器官衰竭评分(SOFA)和急性生理功能与慢性健康状况评分(APACHEⅡ)。结果 :经检测发现10种病菌,其中以鲍曼不动杆菌最为多见、其次为嗜麦芽窄食单胞菌和耐甲氧西林金黄色葡萄球菌;治疗后,患者的白细胞和降钙素原水平均显著低于治疗前,差异具有统计学意义(P<0.05);治疗后,患者APACHEⅡ和SOFA评分明显低于治疗前,差异具有统计学意义(P<0.05)。结论 :替加环素在重症患者经验性抗感染治疗中具有良好效果,有利于控制临床感染,减轻患者病情。

Objective:To explore the clinical efficiency of tigecycline in empirical anti-infection of critical patients.Methods:100 critical cases admitted from March 2016 to March 2017 in ICU of Zhengzhou People's Hospital in Henan Province and treated with tigecycline were enrolled in the study.The culture of the separated strains was recorded.White blood cells and calcitonin levels,as well as sequential organ failure assessment(SOFA) and acute physiological and chronic health evaluation(APACHE Ⅱ) of before and after the treatment were compared.Results:10 bacteria strains were detected,and therein Bauman acinetobacter was the most common strain,followed by Stenotrophomonas maltophilia and methicillin-resistant Staphylococcus aureus.The white blood cells and calcitonin level were significantly lower after the treatment than that before the treatment(P<0.05).Moreover,the APACHE Ⅱ and SOFA scores of patients after treatment were significantly lowered than that before treatment(P<0.05).Conclusion:Tigecycline showed good efficiency in the treatment of empirical anti-infection of critical patients,which was conducive to the control of clinical infection and relieve patients' symptoms.