不同剂量阿托伐他汀治疗冠心病的疗效观察及不良反应

Study on the Effect of Different Doses of Atorvastatin in the Treatment of Coronary Heart Disease and Adverse Reactions

目的 :观察不同剂量阿托伐他汀治疗冠心病的临床疗效与不良反应。方法 :选取本院2016年1-12月收治的150例冠心病患者,按随机数字表法分为两组,各75例。对照组予以阿托伐他汀(10.0 mg,qd)治疗,研究组予以阿托伐他汀(40.0 mg,qd)治疗,比较分析两组血清炎性指标、血脂水平、不良反应。结果 :治疗后,研究组C反应蛋白(CRP)、白细胞介素(IL)-6以及肿瘤坏死因子(TNF)-α,血清总胆固醇(TC)、三酰甘油(TG),低密度脂蛋白胆固醇(LDL-C)均低于对照组,高密度脂蛋白胆固醇(HDL-C)高于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论 :大剂量阿托伐他汀治疗冠心病较小剂量对炎性因子、血脂水平的改善更优,且无明显药物不良反应。

Objective:To observe the clinical efficacy and adverse effects of different doses of atorvastatin in the treatment of coronary heart disease. Methods:150 cases of coronary heart disease admitted to our hospital from January 2016 to December 2016 were randomly divided into two groups, with 75 cases in each group. Patients in control group were treated with atorvastatin(10.0 mg, qd), and patients in the study group were treated with atorvastatin(40.0 mg, qd). The serum inflammatory factors, lipid levels and side effects of the two groups were compared and analyzed. Results:After treatment, c-reactive protein(CRP), interleukin(IL)-6, tumor necrosis factor(TNF)-α, serum total cholesterol(TC), triglyceride(TG), and low density lipoprotein cholesterol(LDL-C) in the study group were lower than those in the control group, while the high density lipoprotein cholesterol(HDL-C) level in the study group was higher than that in the control group(P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion:High dose of atorastatin in improvement of inflammatory factor and lipid levels of coronary heart patient is better than low dose, without obvious adverse drug reaction.