参麦注射液联合盐酸氟桂利嗪治疗脑梗死后血管性痴呆患者的临床疗效

Clinical Efficacy of Shenmai Injection Combined with Flunarizine Hydrochloride in Treatment of Patients with Vascular Dementia after Cerebral Infarction

目的:探讨盐酸氟桂利嗪联合参麦注射液治疗脑梗死后血管性痴呆(VD)的疗效。方法:2012年1月-2016年12月于我院就诊的160例脑梗死后VD患者为研究对象,按随机数字表法分为对照组与治疗组,各80例。对照组给予常规治疗,治疗组在对照组基础上采用盐酸氟桂利嗪(5~10 g,qn)联合参麦注射液(20~100 m L,ivgtt,qd)结合治疗。比较两组的治疗效果。结果:治疗组有效率为97.50%,对照组为85.00%,两组比较差异有统计学意义(P<0.05)。两组治疗前三酰甘油(TG)、低密度脂蛋白(LDL)、血浆同型半胱胺酸(Hcy)比较无统计学差异(P>0.05);治疗后,两组上述三项指标均降低,且治疗组低于对照组(P<0.05)。治疗前,两组的CRP、IL-6比较无统计学差异(P>0.05);治疗后,两组CRP、IL-6指标均降低,且治疗组低于对照组(P<0.05)。治疗前,两组的认知功能、日常生活能力评分比较无统计学差异(P>0.05);治疗后,两组认知功能、日常生活能力评分均提高,且治疗组高与对照组(P<0.05)。结论 :采用盐酸氟桂利嗪联合参麦射液治疗脑梗死后VD,可显著改善其临床症状,提高患者的生活与认知能力。

Objective:To analyze the efficacy of shenmai injection combined with flunarizine hydrochloride in treatment of patients with vascular dementia(VD) after cerebral infarction. Methods:160 patients with VD after cerebral infarction admitted in Shuanghe Hospital of Henan Petroleum Exploration Bureau and Oil Field Staff Hospital of Nanyang from January 2012 to December 2016 were selected as the research subjects. They were randomly divided into the control group and the treatment group, with 80 cases in each group. Patients in the control group were given routine treatment, while patients in the treatment group were treated with flunarizine hydrochloride(5~10 g, qn) combined with shenmai injection(20~100 m L, ivgtt, qd) in addition to the routine treatment in control group. The curative efficacy in the two groups was compared. Results:The total efficiency of the treatment group and control group was 97.50% and 85.00%, respectively, with significant difference between the two groups(P<0.05). Triglyceride(TG), low density lipoprotein(LDL) and plasma homocysteine(Hcy) levels in the two groups before the treatment showed no difference(P>0.05). After treatment, the levels decreased in both groups, and the LDL, TG and plasma Hcy levels in treatment group were smaller than those in the control group(P<0.05). CRP and IL-6 levels in the two groups before the treatment showed no difference(P>0.05). After treatment, the levels decreased in both groups, and the CRP and IL-6 levels in treatment group were smaller than those in the control group(P<0.05). No difference was observed in the cognitive function and daily life ability scores between the two groups before treatment(P>0.05), the cognitive function and daily life ability in both groups were improved after treatment, and indicators in treatment group were significantly higher than those in control group(P<0.05). Conclusion:Flunarizine hydrochloride combined with shenmai injection could obviously improve the clinical symptoms and cognitive function in the treatment of patients with VD after cerebral infarction.