复方血栓通注射液联合低分子肝素钠治疗脑梗死的疗效分析

Analysis of Curative Effect of Compound Xueshuantong Injection Combined with Low Molecular Weight Heparin in the Treatment of Cerebral Infarction

目的 :探讨复方血栓通注射液联合低分子肝素钠治疗脑梗死的疗效。方法 :选取2015年1月-2017年1月我院收治的脑梗死患者60例为研究对象,按随机数字表法分为观察组和对照组,各30例。对照组给予复方血栓通注射液(400 m L,qd)治疗,观察组在对照组基础上加用低分子肝素钠(4 000 IU,qd)皮下注射。比较两组的临床疗效。结果 :观察组治疗有效率明显高于对照组,差异有统计学意义(χ~2=4.320,P<0.05);治疗前,两组神经功能缺损评分(NIHSS)差异无统计学意义(P>0.05);治疗后,观察组NIHSS评分改善情况明显优于对照组,组间差异有统计学意义(t=0.27,P<0.05);两组血小板及凝血酶原时间差异无统计学意义(P>0.05),但观察组血浆黏度和纤维蛋白原下降程度明显优于对照组,差异有统计学意义(P<0.05)。结论 :复方血栓通注射液联合低分子肝素钠治疗脑梗死,可有效改善患者的NIHSS评分、血浆黏度及纤维蛋白原,提高疗效。

Objective:To investigate the curative effect of compound xueshuantong injection combined with low molecular weight heparin in treatment of cerebral infarction. Methods:60 patients with cerebral infarction admitted in Zhengzhou Seventh People's Hospital from January 2015 to January 2017 were selected and randomly divided into the observation group and the control group with 30 cases in each group. Patients in the control group were treated with compound xueshuantong injection(400 m L, qd), while patients in the observation group were subcutaneously injected with low molecular weight heparin(4 000 IU, qd) in addition to the treatment in the control group. The clinical curative effect of the two groups was compared. Results:The total effective rate of the observation group was significantly higher than that of the control group, and the difference between the two groups was statistically significant(χ~2=4.320, P<0.05). Before treatment, NIH stroke scale(NIHSS) score of the two groups showed no significant difference(P>0.05); after treatment, improvement in NIHSS score in the observation group was better than that of the control group, and the difference between the two groups was statistically significant(t=0.27, P<0.05). There was no statistically significant difference in platelet and prothrombin time between the two groups(P>0.05), while the plasma viscosity and degree of fibrinogen decline in the observation group was significantly better than those in the control group(P<0.05). Conclusion:Compound xueshuantong injection combined with low molecular weight heparin could effectively improve the NIHSS score, plasma viscosity and fibrinogen in patients with cerebral infarction, resulting in improved curative effect.