早期注射胰岛素对妊娠期糖尿病患者血糖水平、妊娠结局的影响

Effect of Early Injection of Insulin on Blood Glucose Level and Pregnancy Outcome in Patients with Gestational Diabetes Mellitus

目的:探讨早期注射胰岛素对妊娠期糖尿病患者血糖水平、妊娠结局的影响。方法:选择2015年12月-2016年10月在我院治疗的60例妊娠期糖尿病患者为研究对象,按随机数字表法分为两组,各30例。两组均使用4~6 UI胰岛素按比例分配注射于三餐之前和入睡前。对照组实行晚期治疗(起始孕周>32周),观察组实行早期治疗(起始孕周≤32周)。比较两组患者血糖水平、妊娠结局。结果 :分娩前,观察组空腹血糖(FPG)、2 h餐后血糖(2h PBG)、血糖升高值低于对照组,差异有统计学意义(P<0.05);分娩后,观察组巨大儿、胎儿窘迫发生率明显低于对照组,差异有统计学意义(P<0.05)。结论 :针对妊娠期糖尿病患者早期注射胰岛素能够有效控制血糖水平,改善妊娠结局,促进产妇和新生儿的健康。

Objective:To investigate the effect of early injection of insulin on blood glucose level and pregnancy outcome in patients with gestational diabetes mellitus(GDM). Methods:60 GDM patients treated in our hospital from December 2015 to October 2016 were selected, and the patients were randomly divided into two groups, 30 cases in each group. Two groups were injected with 4-6 UI insulin before meals and before falling asleep. Control group was given late treatment(gestational weeks>32 weeks), while observation group was given early treatment(gestational weeks≤32 weeks). The blood glucose level and pregnancy outcome were compared between the two groups. Results:Before delivery, the values of fasting blood glucose(FPG), 2 h postprandial blood glucose(2 H PBG) and blood glucose increased in the observation group were lower than those in the control group, the difference was statistically significant(P<0.05). After delivery, the incidence of macrosomia and fetal distress in the observation group was significantly lower than that in the control group, the difference was statistically significant(P<0.05). Conclusion:Early insulin injection in patients with gestational diabetes can effectively control the level of blood sugar, improve the pregnancy outcome, and promote the health of the pregnant women and the newborn.