抗高血压药物联合用药分析

Analysis of Antihypertensive Drugs Combination

目的 :探讨临床抗高血压药物联合用药的情况,为临床合理使用抗高血压药物提供参考。方法 :对某院2016年全年收治的抗高血压药物联合用药340例病例,根据联合用药具体的药物类别、药物品种、用药频度、联合用药方案和治疗效果进行统计分析。结果 :联合用药中钙拮抗剂是使用频率和DDDs最高的品种。联合用药方式以二联(47.61%)和三联(25.53%)用药为主,治疗的平均有效率分别为87.71%和72.92%。二联和三联用药方案中,均以含钙拮抗剂的联合用药方案为主。结论:医院抗高血压药物联合应用基本合理,符合中国高血压防治指南的要求,但仍然存在某些不规范的联合用药方案,有待进一步改善。

Objective:To analyze the combined application of antihypertensive drugs and to provide references for the rational use of antihypertensive drugs. Methods:Medical records of 340 hypertensive patients treated with combination of antihypertensive drugs in 2016 in a hospital were statistically analyzed according to the drug classes, categories, defined daily dose system(DDDs), combined regimens and clinical efficacy. Results:Frequency of utilization and DDDs of calcium antagonists are the highest in durgs combination. Dual and triple combinations were the main use form, accounting for 47.61% and 25.53%, respectively, with the average effective rates of 87.71% and 72.92%, respectively. The regimens of dual and triple combination antihypertensive therapies were mainly based on calcium channel blockers. Conclusion:The combinations of antihypertensive drugs used in hospital are generally rational and in line with the medication guideline for hypertension recommended in China, but with some irrational combination regimens and need to be improved.