舒肝颗粒联合黛力新治疗女性更年期抑郁的疗效观察

Observation on Therapeutic Effect of Shugan Granules Combined with Deanxit on Female Climacteric Depression

目的:探讨舒肝颗粒联合黛力新治疗女性更年期抑郁的临床疗效。方法:选取我院2016年1月-2017年1月收治的女性更年期抑郁患者128例,按随机数字表法分为对照组和观察组,各64例。对照组口服黛力新(10.5 mg,早晨、中午各1次),观察组在对照组基础上口服舒肝颗粒(3 g,bid),2个月为一个疗程,比较两组临床疗效和安全性。结果 :观察组治疗总有效率为87.50%,对照组总有效率为56.25%,两组比较差异有统计学意义(P<0.05),两组汉密顿抑郁量表(HAMD)评分均随治疗时间延长而下降,且观察组治疗30 d和治疗60 d HAMD评分均低于对照组(P<0.05)。两组汉密顿焦虑量表(HAMA)评分均随治疗时间延长而下降,且观察组治疗30 d和治疗60 d观察组HAMA评分均低于对照组(P<0.05),两组不良反应比较无统计学差异。结论:舒肝颗粒联合黛力新治疗女性更年期抑郁临床疗效显著,安全,值得临床推广。

Objective:To observe the therapeutic effect of shugan granules combined with deanxit on female climacteric depression. Methods:128 cases of female climacteric depression from January 2016 to January 2017 were randomly divided into control group(n=64) and observation group(n=64). The patients in the control group received deanxit(10.5 mg, once in the morning and noon). The patients in the observation group were further treated with shugan granules(3 g, bid), 2 months as a treatment course. The clinical therapeutic effect and safety were compared. Results:The total effective rate of the observation group was significantly higher than that of the control group(87.50% vs. 56.25%, P<0.05). The scores of Hamilton depression scale(HAMD) in the two groups were decreased with treatment time extension, and the HAMD scores 30 days and 60 days after treatment in the observation group were significantly lower than those in the control group(P<0.05). The scores of Hamilton anxiety scale(HAMA) in the two groups were decreased with treatment time extension, and the HAMA scores 30 days and 60 days after treatment in the observation group were significantly lower than those in the control group(P<0.05). There was no significant difference in adverse reactions between the two groups. Conclusion:The clinical therapeutic effect of shugan granules combined with deanxit on female climacteric depression is remarkable, safe and worthy of promotion.