卡贝缩宫素联合卡前列素氨丁三醇治疗前置胎盘剖宫产产后出血的效果

Effect of Carbetocin Combined with Carboprost Tromethamine in Treating Postpartum Hemorrhage of Caesarean Section of Placenta Previa

目的 :探讨卡贝缩宫素联合卡前列素氨丁三醇治疗前置胎盘剖宫产产后出血的效果及对其预后的影响。方法 :选取2016年1月-2017年12月我院收治的前置胎盘剖宫产患者120例,按随机数字表法分为两组,各60例。对照组使用卡前列素氨丁三醇(250μg)治疗,研究组使用卡前列素氨丁三醇(250μg)联合卡贝缩宫素(100μg)治疗。比较两组患者术后出血与止血情况,各临床疗效等指标的差异。结果 :研究组术中及术后2 h出血量显著少于对照组,止血时间短于对照组(P<0.05);研究组住院时间以及手术时间明显短于对照组(P<0.05);研究组治疗有效率显著优于对照组(P<0.05)。结论 :卡前列素氨丁三醇联合卡贝缩宫素治疗前置胎盘剖宫产能有效促进止血,减少术中术后出血量。

Objective:To investigate the effect of carbetocin combined with carboprost tromethamine in treating postpartum hemorrhage of caesarean section of placenta previa and influence on prognosis. Methods:120 patients with placenta previa in our hospital from January 2016 to December 2017 were randomly divided into control group(n=60) and research group(n=60). The patients in the control group were treated with carboprost tromethamine(250 μg), and the patients in the research group were treated with carboprost tromethamine(250 μg) combined with carbetocin(100 μg). The postoperative bleeding and hemostasis, and differences in clinical efficacy and other indexes were compared between the two groups. Results:The amount of bleeding during operation and 2 h after operation in the research group was significantly less than that in the control group and the time of hemostasis was shorter than that in the control group(P<0.05); the hospitalization time and operative time in the research group were significantly shorter than those in the control group(P<0.05); the effective rate in the research group was significantly better than that in the control group(P<0.05). Conclusion:The combined use of carbetocin combined with carboprost tromethamine in postpartum hemorrhage of caesarean section of placenta previa can effectively promote hemostasis and reduce intraoperative and postoperative bleeding amount.