红花黄色素联合金水宝对原发性肾病综合征患者血脂水平及血液流变学的影响

Effects of Safflower Yellow and Jinshuibao on Blood Lipid Level and Hemorheology in Patients with Primary Nephrotic Syndrome

目的:探讨红花黄色素联合金水宝对原发性肾病综合征患者血脂水平及血液流变学的影响。方法:选择2016年8月-2017年6月本院收治的78例原发性肾病综合征患者,按治疗方法不同分为对照组38例和观察组40例。对照组采用金水宝胶囊(0.33 g×3,tid,po)治疗,观察组采用红花黄色素(80 mg,与200 mL 0.9%氯化钠溶液混合,ivgtt,qd)联合金水宝(同对照组)治疗,比较两组治疗前后24 h尿蛋白定量(Upro)、血清白蛋白(ALB)指标、血脂[三酰甘油(TG)和总胆固醇(TC)]和血液流变学指标变化。结果 :治疗后,观察组Upro、ALB指标的改善均优于对照组(P<0.05);观察组TC、TG指标水平低于对照组(P<0.05)。治疗后,观察组血浆黏度、全血高切黏度、全血低切黏度、血小板聚集率、纤维蛋白原指标水平均显著低于对照组(P<0.05)。结论:原发性肾病综合征患者应用红花黄色素联合金水宝治疗方案,可有效改善血脂水平及血液流变学指标,并降低尿蛋白水平,临床应用疗效确切。

Objective:To investigate the effect of safflower yellow and jinshuibao on blood lipid level and hemorheology in patients with primary nephrotic syndrome. Methods:78 patients with primary nephrotic syndrome admitted to our hospital from August 2016 to June 2017 were selected and divided into control group(38 cases) and observation group(40 cases) according to different treatment methods. The patients in the control group were treated with jinshuibao capsule(0.33 g×3, tid, po), and the patients in the observation group were treated with safflower yellow(80 mg, mixed with 200 mL 0.9% sodium chloride solution, ivgtt, qd) combined with jinshuibao capsule(0.33 g×3, tid, po). 24 h urinary protein(Upro), serum albumin(ALB) index, serum triglyceride(TG), total cholesterol(TC) and the change of blood hemorheological indexes in the two groups were compared. Results:After treatment, the improvement of the indexes of 24 h Upro and ALB in the observation group was better than those in the control group(P<0.05), and the levels of TC and TG in the observation group were lower than those in the control group(P<0.05). After treatment, plasma viscosity, high shear viscosity of whole blood, low shear viscosity of whole blood, platelet aggregation rate, fibrinogen index levels in the observation group were significantly lower than those in the control group(P<0.05). Conclusion:The treatment scheme of safflower yellow combined with jinshuibao capsule can effectively improve blood lipid level and hemorheology indexes and reduce urinary protein level in patients with primary nephrotic syndrome, which has definite clinical effective effect.