卡孕栓与缩宫素联用对防控高危妊娠剖宫产患者术中术后出血的临床疗效研究

Study on Clinical Efficacy of Carboprost Suppository Combined with Oxytocin in Prevention and Control of Intraoperative and Postoperative Hemorrhage in Patients with High-risk Pregnancy Undergoing Cesarean Section

目的 :探究应用缩宫素联合卡孕栓预防高危妊娠剖宫产患者术中及术后出血的临床疗效。方法 :选取2016年1月8日-2017年1月9日于我院妇产科进行剖宫产的148例高危妊娠患者为研究对象,按随机数字表法分为观察组和对照组,各74例。对照组给予注射缩宫素(5 U)。观察组在对照组基础上,术前孕妇舌下含服1 mg卡孕栓,在胎儿分娩结束后,术后直肠给药1 mg卡孕栓。比较两组术中、术后1 d出血量及不良反应情况。结果 :观察组术中和术后1 d内出血量及血红蛋白降低值低于对照组,差异有统计学意义(P<0.05),观察组产后1 d内出血率显著低于对照组,差异有统计学意义(P<0.05)。观察组使用卡前列素氨丁三醇使用率显著低于对照组,差异有统计学意义(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论:卡孕栓联合缩宫素可减少高危妊娠剖宫产患者术中、术后出血量,具有较好的临床应用价值。

Objective:To investigate the clinical efficacy of oxytocin combined with carboprost suppository in preventing intraoperative and postoperative hemorrhage in patients with high-risk pregnancy undergoing cesarean section. Methods:148 patients with high risk pregnancy undergoing cesarean section from January 8, 2016 to January 9, 2017 were selected as subjects and divided into observation group(n=74) and control group(n=74) according to random number table method. The patients in the control group were not given oxytocin injection(5 U); on the basis of the control group, the pregnant women in the observation group were given 1 mg carboprost suppository by sublingual administration before operation, and 1 mg carboprost suppository by postoperative rectal administration 1 h after the delivery of the fetus. Intraoperative and postoperative bleeding volume and adverse reactions in the two groups were compared. Results:The bleeding volume and hemoglobin decrease value during operation and within 1 d after operation in the observation group were significantly lower than those in the control group(P<0.05), and the bleeding rate within 1 d after delivery in the observation group was significantly lower than that in the control group(P<0.05). The use rate of carboprost tromethamine in the observation group was significantly lower than that in the control group(P<0.05). There was no significant difference in adverse reactions between the two groups(P>0.05). Conclusion:Carboprost suppository combined with oxytocin can significantly reduce intraoperative and postoperative bleeding volume in patients with high risk pregnancy undergoing cesarean section, and has good clinical application value.