干扰素栓联合阿奇霉素治疗衣原体、支原体性宫颈炎的临床效果及预后分析

Analysis on Clinical Effect and Prognosis Effect of Interferon Suppository Combined with Azithromycin in the Treatment of Chlamydia and Mycoplasma Cervicitis

目的 :探讨干扰素栓联合阿奇霉素治疗衣原体、支原体性宫颈炎的临床效果及预后,并对其机制进行分析。方法 :选取2014年12月-2016年12月我院收治的衣原体、支原体性宫颈炎患者60例,按随机数字表法分为试验组与对照组,各30例。对照组给予口服阿奇霉素(0.25 g,bid)治疗,试验组给予外用干扰素栓(1粒,qd)联合阿奇霉素(同对照组)治疗,两组均治疗两周后,比较两组康复率、复发率、宫颈分泌物聚合酶链式反应(PCR)检测转阴时间。结果 :试验组康复率显著高于对照组(P<0.05),复发率显著低于对照组(P<0.05),PCR检测转阴时间明显短于对照组(P<0.05)。结论 :采用干扰素栓联合阿奇霉素治疗衣原体、支原体性宫颈炎的疗效优于单一使用阿奇霉素的治疗效果,值得在临床上推广使用。

Objective:To investigate the clinical efficacy and prognosis of interferon suppository combined with azithromycin in the treatment of chlamydia and mycoplasma cervicitis and to analyze its mechanism. Method:60 cases of chlamydia and mycoplasma cervicitis patients who were treated in our hospital from December 2014 to December 2016 were selected and divided into trial group and control group according to the random number table method, 30 cases in each group. The patients in the control group were treated with oral azithromycin(0.25 g, bid), and the patients in the trial group were treated with topical interferon suppository(1 particle, qd) combined with azithromycin(0.25 g, bid). After two weeks of treatment, the recovery rate and recurrence rate in the two groups were compared, and the negative-conversing time of cervical secretion was assayed by polymerase chain reaction(PCR). Results:The recovery rate in the trial group was significantly higher than that in the control group(P<0.05), while the recurrence rate was significantly lower than that in the control group(P<0.05) and the negative-conversing time of cervical secretion assayed by PCR was significantly shorter than that in the control group(P<0.05). Conclusion:Interferon suppository combined with azithromycin used in the treatment of chlamydia and mycoplasma cervicitis is superior to single azithromycin in therapeutic effect, and is worth popularizing in clinical practice.