丁苯酞联合他汀类药物治疗缺血性脑血管病的疗效探讨

Investigation on Efficacy of Butylphthalide Combined with Statins in the Treatment of Ischemic Cerebrovascular Disease

目的:探讨丁苯酞联合他汀类药物治疗缺血性脑血管病的临床疗效。方法:选取2015年7月—2017年8月我院收治的缺血性脑血管病患者90例,按随机数字表法分为治疗组与对照组,各45例。对照组给予阿司匹林(100 mg,qd,po)+氯吡格雷(75 mg,qd,po)+阿托伐他汀(20 mg,qd,po)治疗。治疗组在对照组基础上联合丁苯酞(200 mg,tid,po)治疗。治疗前后分别采用美国国立卫生研究院卒中量表(NIHSS)、蒙特利尔认知评估量表(Mo CA)、日常生活活动能力量表(ADL)评估两组神经功能缺损程度、认知功能及日常生活能力改善情况,比较两组临床疗效。结果:治疗组总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,治疗组NIHSS评分、MoCA评分及ADL评分均优于对照组,差异有统计学意义(P<0.05);治疗组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:丁苯酞联合他汀类药物治疗缺血性脑血管病疗效理想,可改善神经功能缺损程度、提高日常生活活动能力及认知水平,安全可靠。

Objective: To investigate the clinical efficacy of butylphthalide combined with statins in the treatment of ischemic cerebrovascular disease. Methods: 90 patients with ischemic cerebrovascular disease admitted to our hospital from July 2015 to August in 2017 were selected and divided into treatment group and control group according to the random number table method, 45 cases in each group. The patients in the control group were given oral aspirin(100 mg/time, qd, po) in combination with clopidogrel(75 mg/time, qd, po) and atorvastatin(20 mg/time, qd, po). The patients in the treatment group were treated with oral butylphthalide(200 mg/times, tid, po) on the basis of the control group. The degree of nerve function defects, cognitive function and improvement of daily living ability before and after treatment were evaluated by NIH stroke scale(NIHSS), Montreal cognitive assessment scale(Mo CA) and activity of daily living activity scale(ADL), and the clinical efficacy was compared between the two groups. Results: The total effective rate of the treatment group was significantly better than that of the control group(P<0.05). The NIHSS score, Mo CA score and ADL score in the treatment group were significantly better than those in the control group(P<0.05). The incidence of adverse reactions in the treatment group was significantly lower than that in the control group(P<0.05). Conclusion: Butylphthalide combined with statins is ideal for the treatment of ischemic cerebrovascular disease, which can improve the degree of nerve function defects and improve daily living ability and cognitive level, and is safe and reliable.