丁苯酞软胶囊联合重复经颅磁刺激对血管性痴呆患者血清Ang-Ⅰ、MMP-9水平变化的影响

Effects of Butylphthalide Soft Capsule Combined with Repetitive Transcranial Magnetic Stimulation on Changes of Serum Ang-I and MMP-9 Levels in Patients with Vascular Dementia

目的:探讨丁苯酞软胶囊联合重复经颅磁刺激(r TMS)对血管性痴呆(Va D)患者血清血管紧张素(Ang)-Ⅰ、基质金属蛋白酶(MMP)-9水平变化的影响。方法:选取2015年9月—2017年6月我院收治的111例Va D患者,按随机数字表法分为观察组56例与对照组55例。常规治疗基础上,对照组给予丁苯酞软胶囊(200 mg,tid)治疗,观察组在对照组基础上联合r TMS治疗。比较两组临床疗效、治疗前后血清Ang-Ⅰ、MMP-9水平,统计两组治疗期间不良反应发生情况。结果:观察组治疗总有效率为92.86%,高于对照组的80.00%(P<0.05);治疗前两组血清Ang-Ⅰ、MMP-9水平比较差异无统计学意义(P>0.05),治疗后两组血清Ang-Ⅰ、MMP-9水平较治疗前降低,差异有统计学意义(P<0.05),且观察组治疗后血清Ang-Ⅰ、MMP-9水平低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:丁苯酞软胶囊联合r TMS治疗Va D疗效显著,可有效降低血清Ang-Ⅰ、MMP-9水平,安全性好。

Objective: To investigate the effects of butylphthalide soft capsule combined with repetitive transcranial magnetic stimulation(r TMS) on the changes of serum angiotensin(Ang)-Ⅰand matrix metalloproteinase(MMP)-9 levels in patients with vascular dementia(Va D). Methods: 111 cases of Va D patients admitted to our hospital from September 2015 to June 2017 were randomly divided into observation group(56 cases) and control group(55 cases). On the basis of conventional treatment, the patients in the control group were treated with butylphthalide soft capsule(200 mg, tid), and the patients in the observation group were treated by r TMS on the basis of the control group. The clinical efficacy and serum Ang-Ⅰand MMP-9 levels before and after treatment were compared between the two groups, and the incidence of adverse reactions during treatment was statistically analyzed. Results: The total effective rate in the observation group was 92.86%, which was higher than that in the control group(80.0%)(P<0.05). There was no significant difference in serum Ang-Ⅰand MMP-9 levels between the two groups before treatment(P>0.05). The levels of serum Ang-Ⅰand MMP-9 in the two groups after treatment were lower than those before treatment(P<0.05). The levels of serum Ang-Ⅰand MMP-9 after treatment in the observation group were significantly lower than those in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Butylphthalide soft capsule combined with r TMS is effective in the treatment of Va D, which can effectively reduce serum Ang-Ⅰand MMP-9 levels, and has good safety.