枸地氯雷他定治疗慢性荨麻疹的临床疗效和安全性

Clinical Efficacy and Safety of Desloratadine Citrate Disodium in the Treatment of Chronic Urticaria

目的:探讨枸地氯雷他定治疗慢性荨麻疹的临床疗效和安全性。方法:选取2016年1-12月我院收治的慢性荨麻疹患者88例,按随机数字表法分为对照组与观察组,各44例。对照组采用口服氯雷他定片(10 mg,qd)治疗,观察组采用口服枸地氯雷他定片(8.8 mg,qd)治疗,比较两组治疗后的临床疗效及治疗过程中不良反应发生情况。结果:治疗14 d后,观察组治疗总有效率高于对照组,差异具有统计学意义(P<0.05);治疗28 d后,两组临床治疗总有效率差异无统计学意义(P>0.05);两组治疗过程中不良反应发生情况差异无统计学意义(P>0.05)。结论:枸地氯雷他定治疗慢性荨麻疹的临床疗效显著,起效速度快,安全性高,值得推广应用。

Objective:To investigate the clinical efficacy and safety of desloratadine citrate disodium in the treatment of chronic urticaria. Methods:A total of 88 patients with chronic urticaria admitted to our hospital from January 2016 to December 2016 were enrolled and randomly divided into control group(n=44) and observation group(n=44). The patients in the control group were treated with loratadine tablets(10 mg, qd), and the patients in the observation group were treated with desloratadine citrate disodium tablets(8.8 mg, qd). The clinical efficacy and adverse reactions during treatment were compared between the two groups. Results:After 14 days of treatment, the total effective rate in the observation group was higher than that in the control group(P<0.05); after 28 days of treatment, there was no significant difference in the total effective rate between the two groups(P>0.05); there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion:Desloratadine citrate disodium has significant efficacy and quick effect in the treatment of chronic urticaria, which is worthy of promotion and application.