甲强龙冲击治疗小儿神经免疫性疾病的临床疗效观察

Observation on Clinical Efficacy of Methylprednisolone Implosive Therapy in the Treatment of Pediatric Neuroimmune Diseases

目的:探讨甲强龙治疗小儿神经免疫性疾病的临床效果。方法:选取2015年1—12月我院收治的110例神经免疫性疾病患儿为研究对象,按随机数字表法分为两组,各55例。对照组给予常规药物地塞米松磷酸钠(5~15 mg,ivgtt,qd)治疗,观察组采取甲强龙[15 mg/(kg·d)溶于500 m L 5%葡萄糖溶液中,ivgtt,4 d后更换为醋酸泼尼松片1.5 mg/(kg·d),早晨顿服]冲击治疗,比较两组临床效果。结果:治疗后,观察组治疗总有效率明显高于对照组,差异有统计学意义(P<0.05);观察组平均住院时间明显低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率比较差异无统计学意义(P>0.05)。结论:甲强龙冲击治疗小儿神经免疫性疾病临床疗效显著,安全性好,值得推广借鉴。

Objective: To explore the clinical efficacy of methylprednisolone implosive therapy in the treatment of pediatric neuroimmune diseases. Methods: 110 cases of children with neuroimmune diseases admitted to our hospital from January to December 2015 were selected as subjects and divided into two groups according to the random number table method, 55 cases in each group. The children in the control group were treated with conventional drug dexamethasone sodium phosphate(5~15 mg, ivgtt, qd). The children in the observation group were given methylprednisolone [15 mg/(kg·d), dissolved in 500 m L 5% glucose solution, ivgtt, 4 days later, changed to prednisone acetate 1.5 mg/(kg·d), which was taken in morning] implosive therapy. The clinical effect was compared between the two groups. Results: After treatment, the total effective rate in the observation group was significantly higher than that in the control group, and the difference was statistically significant(P<0.05); the average hospitalization time in the observation group was significantly shorter than that in the control group, and the difference was statistically significant(P<0.05);there was no significant difference the incidence of adverse reactions between the two groups(P>0.05). Conclusion: The methylprednisolone implosive therapy has significant clinical efficacy in the treatment of pediatric neuroimmune diseases and good safety, which is worth popularizing.