多奈哌齐片治疗血管性痴呆的近远期疗效观察

Short-term and Long-term Efficacy of Donepezil Tablet in the Treatment of Vascular Dementia

目的:观察多奈哌齐片治疗血管性痴呆的近期及远期疗效。方法:选取2013年6月—2015年6月我院收治的88例血管性痴呆患者,按随机数字表法分为观察组与对照组,各44例。观察组应用盐酸多奈哌齐片(5 mg,qd)治疗,对照组应用脑复康片(0.8 g,tid)治疗。比较两组治疗前后简易精神状态量表(MMSE)评分、日常生活能力量表(ADL)评分、近期及远期总有效率、不良反应发生情况。结果:治疗后,两组MMSE评分与ADL评分均高于治疗前,且观察组MMSE评分与ADL评分高于对照组,差异有统计学意义(P<0.05)。观察组近期与远期总有效率均高于对照组,差异有统计学意义(P<0.05)。两组治疗期间均未见严重不良反应。结论:多奈哌齐治疗血管性痴呆近远期疗效显著,可有效改善认知功能,安全性高。

Objective: To observe the short-term and long-term efficacy of donepezil tablet in the treatment of vascular dementia. Methods: 88 cases of patients with vascular dementia admitted to our hospital from June 2013 to June 2015 were randomly divided into observation group and control group, 44 cases in each group. The patients in the observation group were treated with donepezil hydrochloride tablet(5 mg, qd), and the patients in the control group were treated with piracetam tablet(0.8 g, tid). The scores of mini mental state examination(MMSE) and activity of daily living(ADL) before and after treatment, the short-term and long-term total effective rates and the incidence of adverse reactions were compared between the two groups. Results: The scores of MMSE and ADL in the two groups after treatment were higher than those before the treatment and the scores of MMSE and ADL in the observation group were higher than those in the control group, and the difference was statistically significant(P<0.05). The short-term and long-term total effective rates in the observation group were higher than those in the control group, and the difference was statistically significant(P<0.05). No serious adverse reaction was observed during treatment periods in the two groups. Conclusion: Donepezil has significant short-term and long-term efficacy in the treatment of vascular dementia, and can effectively improve cognitive function, and has high safety.