人绝经期促性腺激素联合来曲唑对多囊卵巢综合征不孕症患者子宫内膜厚度及妊娠结局的影响

Effect of Human Menopausal Conadotropin Combined with Letrozole on Endometrial Thickness and Pregnancy Outcome in Patients with Polycystic Ovary Syndrome-induced Infertility

目的:观察人绝经期促性腺激素(HMG)联合来曲唑对多囊卵巢综合征(PCOS)不孕症患者子宫内膜厚度及妊娠结局的影响。方法:选取2015年6月—2016年6月我院收治的PCOS不孕症患者100例,按随机数字表法分为两组,各50例。对照组给予HMG(75~150 U,qd)治疗,观察组在对照组基础上给予来曲唑(5 mg,qd)治疗。比较两组子宫内膜厚度、成熟卵细胞数、血清睾酮(T)、黄体生成素(LH)、促卵泡激素(FSH)及雌二醇(E2)水平及妊娠结局。结果:治疗后,观察组子宫内膜厚度高于对照组,血清T、LH水平低于对照组,差异有统计学意义(P<0.05);观察组排卵率、妊娠率高于对照组,差异有统计学意义(P<0.05)。结论:HMG联合来曲唑治疗PCOS不孕症,可增加子宫内膜厚度,降低血清T、LH水平,改善妊娠结局。

Objective: To observe the effect of human menopausal gonadotropin(HMG) combined with letrozole on endometrial thickness and pregnancy outcome in patients with polycystic ovary syndrome(PCOS)-induced infertility. Methods: 100 cases of patients with PCOS-induced infertility admitted to our hospital from June 2015 to June 2016 were randomly divided into control group and observation group, 50 cases in each group. The patients in the control group received HMG(75~150 U, qd) treatment. The patients in the observation group were treated with letrozole(5 mg, qd) on the basis of the control group. Endometrial thickness, mature egg cell, serum testosterone(T), luteinizing hormone(LH), follicle stimulating hormone(FSH), estradiol(E2) and pregnancy outcome were compared between the two groups. Results: After treatment, the thickness of endometrium in the observation group was higher than that in the control group and the levels of serum T and LH were lower than those in the control group, and the difference was statistically significant(P<0.05); the ovulation rate and the pregnancy rate in the observation group were higher than those in the control group, and the difference was statistically significant(P<0.05). Conclusion:HMG combined with letrozole in the treatment of PCOS-induced infertility can increase the thickness of patient's endometrium, reduce serum T and LH levels and improve their pregnancy outcome.