大剂量洛赛克联合内镜止血疗法治疗消化性胃溃疡出血的疗效观察

Observation on Efficacy of High-dose Losec Combined with Endoscopic Hemostasis in the Treatment of Peptic Gastric Ulcer Accompanied by Hemorrhage

目的:研究大剂量洛赛克联合内镜止血疗法治疗消化性胃溃疡出血的疗效。方法:选取2014年5月—2016年3月我院收治的120例消化性胃溃疡出血患者为研究对象,根据治疗方法不同分为三组,各40例。A组给予常规剂量洛赛克(20 mg,qd)治疗,B组给予中等剂量洛赛克(40 mg,bid)联合内镜止血疗法治疗,C组给予大剂量洛赛克(80 mg,tid)联合内镜止血疗法治疗。比较三组治疗效果、平均止血时间及平均住院时间。结果:C组治疗总有效率明显高于A、B两组,差异有统计学意义(P<0.05);C组平均止血时间、住院时间均短于A、B两组,差异有统计学意义(P<0.05)。结论:大剂量洛赛克联合内镜止血疗法治疗消化性胃溃疡出血疗效显著,能够缩短止血时间,缓解疼痛,加快溃疡面恢复,值得临床推广应用。

Objective: To study the efficacy of high-dose Losec combined with endoscopic hemostasis in the treatment of peptic gastric ulcer accompanied by hemorrhage. Methods: 120 patients with peptic gastric ulcer admitted to our hospital from May 2014 to March 2016 were enrolled in the study and divided into three groups according to different treatment methods, 40 cases in each group. The patients in the group A were given a conventional dose of Losec(20 mg, qd). The patients in the group B were given a medium dose of Losec(40 mg, bid) combined with endoscopic hemostasis. The patients in the group C were given a high dose of Losec(80 mg, tid) combined with endoscopic hemostasis. The treatment effects, mean hemostasis time and average hospitalization time were compared between the three groups. Results: The total effective rate in the group C was significantly higher than that in the groups A and B(P<0.05). The average hemostasis time and hospitalization time in the group C were significantly shorter than those in the groups A and B(P<0.05). Conclusion: High-dose Losec combined with endoscopic hemostasis is effective in treating peptic gastric ulcer accompanied by hemorrhage, which can shorten hemostasis time, relieve pain and accelerate the recovery of ulcer surface, and is worthy of clinical application.