盐酸利托君与硫酸镁治疗先兆早产的临床效果比较

Comparison of Clinical Efficacy of Ritodrine Hydrochloride and Magnesium Sulfate in the Treatment of Threatened Premature Labor

目的:比较研究盐酸利托君与硫酸镁治疗先兆早产的效果。方法:选取2016年2月—2017年1月我院收治的100例先兆早产孕妇,按随机数字表法分为两组,各50例。硫酸镁组采用硫酸镁注射液(首次负荷剂量4 g/30 min静脉滴注,后以1~2 g/h维持)治疗;盐酸利托君组采用盐酸利托君(100 mg混合500 m L5%葡萄糖注射液中静脉滴注,初始剂量0.05 mg/min,每分钟加量0.05~0.35 mg/min,至0.10~0.40 mg/min维持)治疗。比较两组胎龄延长时间、新生儿Apgar评分、保胎成功率、不良反应发生情况。结果 :盐酸利托君组胎龄延长时间、新生儿Apgar评分、保胎成功率均明显高于硫酸镁组(P<0.05);盐酸利托君组呼吸抑制、肌无力发生率低于硫酸镁组,而心悸和胸闷发生率高于硫酸镁组,差异均有统计学意义(P<0.05)。结论 :盐酸利托君治疗先兆早产的疗效优于硫酸镁,可提高保胎成功率,延长胎龄,改善新生儿结局,且安全性高。

Objective: To compare the efficacy of ritodrine hydrochloride and magnesium sulfate in the treatment of threatened premature labor. Methods: 100 pregnant women with threatened premature labor admitted to our hospital from February 2016 to January 2017 were selected and randomly divided into magnesium sulfate group and ritodrine hydrochloride group, 50 cases in each group. The patients in magnesium sulfate group were treated with magnesium sulfate injection(intravenous infusion at 4 g/30 min loading dose for the first time and then maintenance at 1~2 g/h). The patients in ritodrine hydrochloride group were treated with ritodrine hydrochloride(100 mg mixed with 500 m L 5% glucose injection for intravenous infusion, initial dose of 0.05 mg/min, increased 0.05~0.35 mg/min per minute to 0.10~0.40 mg/min for maintenance). The prolongation time of gestational age, neonatal Apgar scores, success rate of fetal protection and adverse reactions were compared between the two groups. Results: The prolongation time of gestational age, neonatal Apgar scores and success rate of fetal protection in the ritodrine hydrochloride group were significantly higher than those in the magnesium sulfate group(P<0.05). The incidences of respiratory depression and myasthenia in the ritodrine hydrochloride group were lower than those in the magnesium sulfate group, while the incidences of palpitations and chest tightness were significantly higher than those in the magnesium sulfate group(P<0.05). Conclusion: Ritodrine hydrochloride is superior to magnesium sulfate in the treatment of threatened premature labor, which can improve the success rate of fetal protection, prolong gestational age and improve neonatal outcomes, and has high safety.