脑蛋白水解物联合神经节苷脂对痉挛性脑瘫患儿粗大运动功能及智力发育的影响

Effect of Brain Protein Hydrolysate Combined with Ganglioside on Gross Motor Function and Intellectual Development in Children with Spastic Cerebral Palsy

目的 :探讨脑蛋白水解物联合神经节苷脂对痉挛性脑瘫患儿粗大运动功能及智力发育的影响。方法 :选取2015年1月—2017年1月我院收治的92例痉挛性脑瘫患儿为研究对象,按随机数字表法分为两组,各46例。对照组予以康复训练,研究组在对照组的基础上予以脑蛋白水解物(10 mL,qd)+神经节苷脂(20 mg,qd),两组持续治疗5个疗程。比较两组粗大运动功能评分(GMFM)及智力发育情况。结果:治疗后研究组GMFM评分中E项、D项评分高于对照组,差异有统计学意义(P <0.05);治疗后研究组个人社交行为、大运动行为、语言行为评分均高于对照组,差异有统计学意义(P <0.05)。结论 :脑蛋白水解物联合神经节苷脂可改善痉挛性脑瘫患儿粗大运动功能,促进智力发育。

Objective: To investigate the effect of brain protein hydrolysate combined with ganglioside on gross motor function and intellectual development in children with spastic cerebral palsy. Methods: 92 children with spastic cerebral palsy admitted to our hospital from January 2015 to January 2017 were selected as subjects investigated and randomly divided into two groups, 46 cases in each group. The children in the control group were given rehabilitation training. The children in the study group were given brain protein hydrolysate (10 mL, qd) + ganglioside (20 mg, qd) on the basis of the control group. The children in the two groups were treated for 5 treatment courses. The gross motor function measure (GMFM) and intellectual development were compared between the two groups. Results: After treatment, the E item and D item in the GMFM scores in the study group were significantly higher than those in the control group (P<0.05). After the treatment, the personal social behavior, gross motor behavior and language behavior scores in the study group were significantly higher than those in the control group (P<0.05). Conclusion: Brain protein hydrolysate combined with ganglioside can improve gross motor function and promote intellectual development in children with spastic cerebral palsy.