柴胡消渴汤治疗糖尿病胰岛素抵抗的疗效观察

Observation on Efficacy of Chaihu Xiaoke Decoction on Diabetic Insulin Resistance

目的 :探讨柴胡消渴汤治疗糖尿病胰岛素抵抗的临床效果。方法 :选取2016年5月—2017年5月我院收治的糖尿病合并胰岛素抵抗患者94例为研究对象,采用随机数字表法分为两组,各47例。对照组接受常规治疗,研究组在对照组基础上给予柴胡消渴汤(每日1剂,水煎取汁400 mL,分2次服用)治疗,比较两组治疗前后血糖、外周胰岛素改善程度以及不良反应发生情况。结果 :研究组治疗总有效率明显高于对照组,差异有统计学意义(P <0.05);治疗后两组空腹血糖(FPG)、餐后2 h血糖(2 hBG)以及糖化血红蛋白(HbA1c)较治疗前下降,且研究组低于对照组,差异有统计学意义(P <0.05);治疗后两组胰岛素抵抗指数(HOMA-IR)、空腹胰岛素(FINS)较治疗前降低,且研究组低于对照组;β细胞功能稳态模型评估(HOMA-β)、胰岛素敏感指数(ISI)较治疗前升高,且研究组高于对照组,差异均有统计学意义(P <0.05);研究组用药期间不良反应发生率明显低于对照组,差异有统计学意义(P <0.05)。结论 :柴胡消渴汤治疗胰岛素抵抗的临床效果显著,可有效调节血糖,改善胰岛素抵抗指标,且安全性高,值得推广。

Objective: To investigate the clinical effect of chaihu xiaoke decoction in the treatment of diabetic insulin resistance. Methods: 94 patients with diabetes mellitus complicated with insulin resistance admitted to our hospital from May 2016 to May 2017 were selected as subjects investigated and randomly divided into two groups. 47 patients in each group. The patients in the control group received routine treatment, and the patients in the study group were given chaihu xiaoke decoction (1 dose per day, 400 mL of decoction juice, taken twice) on the basis of the control group. The improvement of blood glucose and peripheral insulin before and after treatment and adverse reactions were compared between the two groups. Results: The total effective rate in the study group was significantly higher than that in the control group (P<0.05). The levels of fasting blood glucose (FPG), postprandial 2 h blood glucose (2 hBG) and glycated hemoglobin (HbA1 c) in the two groups after treatment were lower than those before treatment, and the levels in the study group were lower than those in the control group. The homeostasis model assessment of insulin resistance (HOMA-IR) and fasting insulin (FINS) in the two groups after treatment were lower than those before treatment, and they in the study group were lower than those in the control group;the homeostasis model assessment of β cells (HOMA-β) and insulin sensitivity index (ISI) were higher than those before treatment, and they in the study group were higher than those in the control group (P<0.05). The incidence of adverse reactions during administration in the study group was significantly lower than that in the control group (P<0.05). Conclusion: Chaihu xiaoke decoction has significant clinical effect in treating insulin resistance, and can effectively regulate blood glucose and improve insulin resistance index, and is safe and is worth popularizing.