丹红注射液应用于骨质疏松症治疗的效果观察

Observation on Efficacy of Danhong Injection in the Treatment of Osteoporosis

目的 :研究丹红注射液治疗骨质疏松症的临床效果。方法 :选取2016年1月—2017年6月我院收治的骨质疏松症患者100例为研究对象,按随机数字表法分为对照组和试验组,各50例。对照组给予钙尔奇D片(1片,qd)治疗,试验组在对照组基础上给予丹红注射液(4 mL加入20 mL 50%葡萄糖注射液稀释后缓慢静脉注射,qd)治疗。比较两组疗效,治疗前后骨密度、血磷、血钙和碱性磷酸酶水平。结果:试验组总有效率显著高于对照组,差异有统计学意义(P <0.05);治疗前,两组血钙、血磷、碱性磷酸酶比较,差异无统计学意义(P> 0.05);治疗后,试验组碱性磷酸酶显著低于对照组,差异有统计学意义(P <0.05);治疗前,两组腰椎、股骨颈、股骨大转子骨密度比较,差异无统计学意义(P> 0.05);治疗后,试验组腰椎、股骨颈、股转大转子骨密度显著高于对照组,差异有统计学意义(P <0.05)。结论 :丹红注射液联合钙尔奇D治疗骨质疏松症的疗效显著,可提高骨密度,降低碱性磷酸酶水平,值得临床推广应用。

Objective: To study the clinical efficacy of danhong injection in the treatment of osteoporosis. Methods: 100 patients with osteoporosis admitted to our hospital from January 2016 to June 2017 were selected as subjects investigated and randomly divided into control group and experimental group. 50 patients in each group. The patients in the control group were treated with caltrate D tablets (1 tablet, qd), and the patients in the experimental group were treated with danhong injection (4 mL added to 20 mL 50% glucose injection and slowly intravenously injected, qd). The efficacy, bone mineral density, blood phosphorus, serum calcium and alkaline phosphatase before and after treatment were compared between the two groups. Results: The total effective rate in the experimental group was significantly higher than that in the control group (P<0.05). Before treatment, there were no significant differences in serum calcium, blood phosphorus and alkaline phosphatase between the two groups (P>0.05). After treatment, the alkaline phosphatase in the experimental group was significantly lower than that in the control group (P<0.05). Before treatment, there was no significant difference in the bone mineral density of lumbar vertebrae, femoral neck and femoral trochiter (P>0.05). After treatment, the bone mineral density of lumbar vertebrae, femoral neck and femoral trochiter in the experimental group was significantly higher than that in the control group (P<0.05). Conclusion: Danhong injection combined with caltrate D has significant curative effect on osteoporosis, and can increase bone density and reduce alkaline phosphatase level, which is worthy of clinical application.