布地奈德混悬液联合双歧杆菌乳杆菌三联活菌片对支气管哮喘的治疗效果

Effect of Budesonide Suspension Combined with Bifidobacterium and Lactobacillus Triple Viable Tablets on Lung Function and Serum Levels of NGF and CKLF-1 in Children with Bronchial Asthma

目的 :探究布地奈德混悬液联合双歧杆菌乳杆菌三联活菌片对支气管哮喘患儿肺功能及血清神经生长因子(NGF)、趋化素样因子(CKLF)-1水平的影响。方法 :选取2015年5月—2017年5月我院收治的104例支气管哮喘患儿,按随机数字表法分为两组,各52例。对照组予以常规治疗,试验组在对照组基础上予以布地奈德混悬液(1 mg,加入3 mL氯化钠注射液,雾化吸入15 min,bid)+双歧杆菌乳杆菌三联活菌片(1.5 g,tid)治疗,连续治疗3个月。比较两组肺功能指标[第1 s用力呼气容积(FEV1)、第1 s用力呼气量占用力肺活量比值(FEV1/FVC)]变化情况、血清NGF、CKLF-1水平及不良反应情况。结果 :治疗后试验组FEV1/FVC、FEV1水平高于对照组,差异有统计学意义(P <0.05);治疗后试验组血清NGF、CKLF-1水平低于对照组,差异有统计学意义(P <0.05);两组不良反应发生率比较,差异无统计学意义(P> 0.05)。结论 :布地奈德混悬液联合双歧杆菌乳杆菌三联活菌片可改善支气管哮喘患儿肺功能,降低血清CKLF-1、NGF水平,且安全性较高。

Objective: To investigate the effect of budesonide suspension combined with Bifidobacterium and Lactobacillus triple viable tablets on lung function and serum levels of nerve growth factor(NGF) and chemokinelike factor(CKLF)-1 in children with bronchial asthma. Methods: 104 children with bronchial asthma admitted to our hospital from May 2015 to May 2017 were randomly divided into two groups, 52 cases in each group. The children in the control group were given conventional therapy, and the children in the experimental group were continuously treated with budesonide suspension(1 mg, added to 3 mL sodium chloride injection, nebulization for 15 min, bid) plus Bifidobacterium and Lactobacillus triple viable tablets(1.5 g, tid) for 3 months. The changes of lung function indexes [forced expiratory volume in 1 second(FEV1), the ratio of forced expiratory volume in 1 second to forced vital capacity(FEV1/FVC)], serum NGF, CKLF-1 levels and adverse reactions were compared between the two groups. Results: The levels of FEV1/FVC and FEV1 in the experimental group were significantly higher than those in the control group(P<0.05). The levels of serum NGF and CKLF-1 in the experimental group were significant lower than those in the control group after treatment(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Budesonide suspension combined with Bifidobacterium and Lactobacillus triple viable tablets can improve the lung function of children with bronchial asthma and reduce serum levels of NGF and CKLF-1, and has high safety.