孟鲁司特钠、氯雷他定联合糠酸莫米松治疗儿童过敏性鼻炎并腺样体肥大的临床疗效研究

Study on Clinical Efficacy of Montelukast Sodium and Loratadine Combined with Mometasone Furoate in the Treatment of Allergic Rhinitis and Adenoidal Hypertrophy in Children

目的 :探讨孟鲁司特钠、氯雷他定联合糠酸莫米松治疗儿童过敏性鼻炎并腺样体肥大的临床疗效。方法 :选择我院150例过敏性鼻炎并腺样体肥大儿童患者为研究对象,随机分为3组,各50例。A组给予孟鲁司特钠(5 mg,qd)、氯雷他定(5 mg,qd)治疗,B组给予糠酸莫米松治疗,两侧鼻孔每天各喷1次,根据症状逐渐减量,C组给予孟鲁司特钠、氯雷他定联合糠酸莫米松治疗,药物使用方法剂量同A组与B组。比较三组的治疗效果。结果:C组过敏性鼻炎、腺样体肥大总有效率明显高于A组、B组(P <0.05);C组呼吸相关睡眠障碍症状指标评分及腺样体厚度与鼻咽宽度之比均低于A组、B组,差异有统计学意义(P <0.05); C组复发率显著低于A组、B组,差异有统计学意义(P <0.05)。结论 :孟鲁司特钠、氯雷他定联合糠酸莫米松治疗儿童过敏性鼻炎并腺样体肥大的临床疗效显著,降低复发率。

Objective: To investigate the clinical efficacy of montelukast sodium and loratadine combined with mometasone furoate in the treatment of allergic rhinitis and adenoidal hypertrophy in children. Methods: 150 children with allergic rhinitis and adenoidal hypertrophy admitted to our hospital were selected as subjects investigated and randomly divided into 3 groups, 50 cases in each group. The patients in the group A were treated with montelukast sodium(5 mg, qd) and loratadine(5 mg, qd). The patients in the group B were given mometasone furoate by spraying both-side nostrils once a day, and the dose was gradually reduced according to symptoms. The patients in the group C were given montelukast sodium and loratadine combined with mometasone furoate. The use method and dose of the drugs were the same as those in the group A and the group B. The therapeutic effects in the three groups were compared. Results: The total effective rate on allergic rhinitis and adenoid hypertrophy in the group C was significantly higher than that in the group A and the group B(P<0.05). The scores of respiratory-related sleep disorder symptoms and the ratio of adenoid thickness to nasopharyngeal width in the group C were lower than those in the group A and the group B, and the difference was statistically significant(P<0.05). The recurrence rate in the group C was significantly lower than that in the group A and the group B, and the difference was statistically significant(P<0.05). Conclusion: Montelukast sodium and loratadine combined with mometasone furoate have a significant clinical effect on allergic rhinitis and adenoidal hypertrophy in children, and reduce the recurrence rate.