安宫黄体酮联合抗菌药治疗子宫内膜炎的临床效果研究

Study on Clinical Effect of Medroxyprogesterone 17-acetate Combined with Antimicrobials in the Treatment of Endometritis

目的:探究安宫黄体酮联合抗菌药治疗子宫内膜炎的临床效果。方法 :选择我院2016年3月—2017年3月收治的94例子宫内膜炎患者按照随机数字表达分为联合组和常规组,各47例。常规组予以甲硝唑(首次给药剂量为15 mg/kg,维持剂量为7.5 mg/kg,每6～8 h注射1次)治疗,联合组予以安宫黄体酮(10 mg,qd,po)+甲硝唑治疗。比较两组临床疗效、治疗前后血清C反应蛋白、肿瘤坏死因子(TNF)-α和子宫内膜组织基质金属蛋白酶(MMP)-9水平变化情况。结果 :联合组治疗总有效率高于常规组,差异有统计学意义(P <0.05);治疗14 d后,两组血清C反应蛋白、TNF-α和子宫内膜组织MMP-9水平均较治疗前降低,且联合组低于常规组,差异有统计学意义(P <0.05)。结论 :安宫黄体酮联合抗菌药可有效改善子宫内膜炎患者的临床症状,减轻炎症反应,促进子宫内膜修复。

Objective:To explore the clinical effect of medroxyprogesterone 17-acetate combined with antimicrobials in the treatment of endometritis.Methods:94 patients with endometritis admitted to our hospital from March 2016 to March 2017 were selected and randomly divided into a combined group and a conventional group,47 cases each.The patients in the conventional group were treated with metronidazole(first dose:15 mg/kg,maintenance dose:7.5 mg/kg,once every 6~8 hours),and the patients in the combined group were treated with medroxyprogesterone 17-acetate(10 mg,qd,po)and metronidazole.The clinical efficacy,serum C-reactive protein,tumor necrosis factor(TNF)-αand endometrial tissue matrix metalloproteinase(MMP)-9 levels were compared between the two groups.Results:The total effective rate in the combined group was higher than that in the conventional group,and the difference was statistically significant(P<0.05).The levels of serum C-reactive protein,TNF-αand endometrial tissue MMP-9 in the two groups after 14 days of treatment were lower than those before treatment,and the levels in the combined group were lower than those in the conventional group,with statistically significant differences(P<0.05).Conclusion:Medroxyprogesterone 17-acetate combined with antimicrobials can effectively improve the clinical symptoms of patients with endometritis,reduce inflammation response and promote endometrial repair.