卡介菌多糖核酸联合膦甲酸钠治疗带状疱疹的疗效观察及对患者免疫功能的影响

Observation on Efficacy of BCG Polysaccharide Nucleic Acid Combined with Foscarnet Sodium in the Treatment of Herpes Zoster and Its Effect on Immune Function of Patients

目的:研究卡介菌多糖核酸联合膦甲酸钠治疗带状疱疹的疗效及对患者免疫功能的影响。方法 :选取2016年2月—2017年5月我院收治的带状疱疹患者98例,按随机数字表法分为对照组和研究组,各49例。对照组给予膦甲酸钠(1.92 g^+0.9%氯化钠注射液250 mL静脉滴注,qd)治疗,研究组在对照组基础上加用卡介菌多糖核酸(1 mL,肌肉注射,3次/周)治疗。比较两组临床疗效、不良反应以及不同时点疼痛视觉模拟评分(VAS),比较两组治疗前后免疫功能指标水平。结果 :研究组治疗有效率明显高于对照组,差异有统计学意义(P <0.05);治疗后,研究组CD4^+、CD8^+及CD4^+/CD8^+明显高于对照组,差异有统计学意义(P <0.05);研究组不同时点VAS评分明显低于对照组,差异有统计学意义(P <0.01);两组不良反应发生率比较,差异无统计学意义(P> 0.05)。结论:卡介菌多糖核酸联合膦甲酸钠治疗带状疱疹疗效确切,能够有效缓解疼痛,提高免疫力,且安全性较好,值得临床推广。

Objective:To study the efficacy of BCG polysaccharide nucleic acid combined with foscarnet sodium in the treatment of herpes zoster and its effect on immune function of the patients.Methods:98 patients with herpes zoster admitted to our hospital from February 2016 to May 2017 were selected and randomly divided into a control group and a study group,49 cases each.The patients in the control group were treated with foscarnet sodium(1.92 g^+0.9%sodium chloride injection 250 mL,intravenous drip,qd),and the patients in the study group were further treated with BCG polysaccharide nucleic acid(1 mL,intramuscular injection,3 times/week).The clinical efficacy,adverse reactions and pain visual analogue scale(VAS)scores at different time points were compared between the two groups,and the levels of immune function indexes before and after treatment were compared between the two groups.Results:The effective rate of the treatment in the study group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of CD4^+,CD8^+and CD4^+/CD8^+in the study group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).The VAS scores at different time points in the study group were significantly lower than those in the control group,and the difference was statistically significant(P<0.01).There was no statistically significant difference in the incidence of adverse reactions(P>0.05).Conclusion:BCG polysaccharide nucleic acid combined with foscarnet sodium is effective in the treatment of herpes zoster,which can effectively relieve pain and improve immunity,and has good safety,so it is worthy of clinical promotion.