川芎嗪注射液联合硝苯地平治疗妊娠期高血压的疗效分析

Analysis on Efficacy of Ligustrazine Injection Combined with Nifedipine in the Treatment of Hypertensive Disorder Complicating Pregnancy

目的:分析川芎嗪注射液联合硝苯地平治疗妊娠期高血压(HDCP)的疗效。方法 :选取我院2016年2月—2018年1月收治的HDCP患者92例,按随机数字表法分为两组,各46例。对照组予以硝苯地平(10 mg,tid)治疗,观察组予以川芎嗪注射液(120 mg加入5%250 mL葡萄糖注射液,ivgtt,qd)+硝苯地平(同对照组)治疗。比较两组临床疗效、妊娠结局及治疗前后血压[收缩压(SBP)、舒张压(DBP)]水平。结果 :观察组治疗总有效率(91.30%)高于对照组(73.91%),差异有统计学意义(P <0.05);治疗后观察组血压水平低于对照组,差异有统计学意义(P <0.05);观察组剖宫产、产后出血、早产、宫缩乏力、新生儿窒息、胎儿窘迫等不良妊娠结局发生率低于对照组,差异有统计学意义(P <0.05)。结论 :川芎嗪注射液联合硝苯地平治疗HDCP的疗效显著,可促使患者血压下降,改善母婴结局。

Objective:To analyze the efficacy of ligustrazine injection combined with nifedipine in the treatment of hypertensive disorder complicating pregnancy(HDCP).Methods:92 patients with HDCP admitted to our hospital from February 2016 to January 2018 were selected and randomly divided into two groups,46 cases each.The patients in the control group were treated with nifedipine(10 mg,tid),and the patients in the observation group were treated with ligustrazine injection(120 mg drug was added to 5%250 mL glucose injection,ivgtt,qd)+nifedipine(the same as control group).The clinical efficacy,pregnancy outcomes and blood pressure[SBP,diastolic blood pressure(DBP)]levels were compared between the two groups.Results:The total effective rate in the observation group(91.30%)was higher than that in the control group(73.91%),and the difference was statistically significant(P<0.05).After treatment,the blood pressure levels in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The adverse pregnancy outcomes such as cesarean section,postpartum hemorrhage,premature delivery,uterine atony,neonatal asphyxia and fetal distress in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:Ligustrazine injection combined with nifedipine is significantly effective in the treatment of HDCP,which can promote the decline of blood pressure and improve maternal and infant outcomes.