柴胡口服液治疗小儿低热的疗效及安全性评价

Evaluation on Efficacy and Safety of Radix Bupleuri Oral Liquid in the Treatment of Low Fever in Children

目的:探讨柴胡口服液治疗小儿低热的疗效及安全性评价。方法:选取2016年5月—2018年5月我院收治的48例低热患儿,按照随机数字表法分为观察组和对照组,各24例。对照组给予注射用头孢呋辛钠(50~100 mg/kg,分早晚两次静脉滴注)治疗,观察组给予柴胡口服液(10 mL,po,每天3~4次)治疗。比较两组临床疗效、中医症状积分以及安全性。结果:观察组总有效率(87.50%)明显高于对照组(79.17%),差异有统计学意义(P <0.05);治疗前两组中医症状积分比较差异无统计学意义(P> 0.05);治疗后两组中医症状积分较治疗前均降低,且观察组低于对照组,差异有统计学意义(P <0.05);两组均未出现明显不良反应。结论:柴胡口服液治疗小儿低热的疗效理想,可降低中医症状积分,且安全可靠。

Objective:To investigate the efficacy and safety of radix bupleuri oral liquid in the treatment of low fever in children.Methods:48 children with low fever admitted to our hospital from May 2016 to May 2018 were selected and randomly divided into an observation group and a control group,24 cases each.The children in the control group were given cefuroxime sodium for injection(50~100 mg/kg,intravenous infusion twice in the morning and evening),and the children in the observation group were given radix bupleuri oral liquid(10 mL,po,3~4 times a day).The clinical efficacy,TCM symptom scores and safety were compared between the two groups.Results:The total effective rate in the observation group(87.50%)was signi?cantly higher than that in the control group(79.17%),and the difference was statistically signi?cant(P<0.05).There was no statistically signi?cant difference in TCM symptom scores before treatment between the two groups(P>0.05).The scores of TCM symptoms in the two groups after treatment were lower than those before treatment,and the scores in the observation group were lower than those in the control group,with statistically signi?cant differences(P<0.05).There were no obvious adverse reactions in the two group.Conclusion:The radix bupleuri oral liquid is ideal in the treatment of low fever in children,which can reduce TCM symptom scores,and is safe and reliable.