帕利哌酮对精神活性物质所致精神障碍患者血清BDNF表达的影响

Effect of Paliperidone on Serum BDNF Expression in Patients with Mental Disorders Caused by Psychoactive Substances

目的:探讨采用帕利哌酮治疗精神活性物质所致精神障碍对患者血清脑源性神经营养因子(BDNF)表达的影响。方法:选取2016年3月—2018年10月在我院就诊的精神活性物质所致精神障碍患者78例,根据随机数字表法分为两组,各39例。对照组采用利培酮(1~2 mg,bid)治疗,观察组采用帕利哌酮(3 mg,qd)治疗,比较两组BDNF水平、阳性与阴性症状量表(PANSS)评分及不良反应发生情况。结果:两组治疗后BDNF水平均明显高于治疗前,差异有统计学意义(P <0.05);两组治疗后BDNF水平、阳性症状及一般精神病理评分比较,差异无统计学意义(P> 0.05);观察组治疗后阴性症状评分及总分较对照组低,差异有统计学意义(P <0.05);观察组实验室检查及神经系统方面副作用发生率低于对照组,差异有统计学意义(P <0.05)。结论:帕利哌酮可显著升高精神活性物质所致精神障碍患者血清BDNF表达,改善患者临床症状,且安全性高。

Objective:To investigate the effect of paliperidone on the expression of serum brain-derived neurotrophic factor(BDNF)in patients with mental disorders caused by psychoactive substances.Methods:78 patients with mental disorders caused by psychoactive substances admitted to our hospital from March 2016 to October 2018 were selected and randomly divided into two groups,39 cases each.The patients in the control group were treated with risperidone(1~2 mg,bid),and the patients in the observation group were treated with paliperidone(3 mg,qd).The level of BDNF,positive and negative symptom scale(PANSS)scores and adverse reaction were compared between the two groups.Results:The levels of BDNF in the two groups after treatment were signi?cantly higher than those before treatment,and the difference was statistically significant(P<0.05).There were no statistically significant differences in BDNF levels,positive symptoms and general psychopathological scores after treatment between the two groups(P>0.05).The negative symptom scores and total scores in the observation group were lower than those in the control group,and the differences were statistically signi?cant(P<0.05).The incidences of adverse reaction in laboratory examination and nervous systems in the observation group were lower than those in the control group,and the differences were statistically signi?cant(P<0.05).Conclusion:Paliperidone can signi?cantly increase serum BDNF expression in the patients with mental disorders caused by psychoactive substances and improve clinical symptoms,and has high safety.