替考拉宁与万古霉素治疗革兰阳性菌感染的细菌清除率及不良反应比较

Comparison of Bacterial Clearance Rate and Adverse Reactions Between Teicoplanin and Vancomycin in the Treatment of Gram-positive Bacterial Infections

目的:比较替考拉宁与万古霉素治疗革兰阳性菌感染的细菌清除率及不良反应。方法:回顾性分析2017年5月—2018年11月本院重症监护室内114例革兰阳性菌感染患者的临床资料,根据治疗方法不同分为替考拉宁组和万古霉素组,各57例。替考拉宁组给予替考拉宁(0.4 g加入0.9%氯化钠注射液100 mL中,ivgtt,q12h)治疗,万古霉素组给予万古霉素(1.0 g加入0.9%氯化钠注射液100 mL中,ivgtt,q12h)治疗。观察两组临床疗效、细菌清除率及不良反应发生情况。结果:两组治疗总有效率及细菌清除率比较,差异无统计学意义(P> 0.05);万古霉素组不良反应发生率高于替考拉宁组,差异有统计学意义(P <0.05)。结论:替考拉宁与万古霉素治疗革兰阳性菌感染效果及细菌清除率相当,但替考拉宁的安全性更高。

Objective:To compare the bacterial clearance rate and adverse reactions of teicoplanin and vancomycin in the treatment of Gram-positive bacterial infections.Methods:The clinical data of 114 patients with Gram-positive bacterial infections in ICU from May 2017 to November 2018 were retrospectively analyzed,and the patients were divided into a teicoplanin group and a vancomycin group according to different treatment methods,57 cases each.The patients in the teicoplanin group were treated with teicoplanin(0.4 g drug was added to 0.9%sodium chloride injection 100 mL,ivgtt,q12 h),and the patients in the vancomycin group were treated with vancomycin(1.0 g drug was added to 0.9%sodium chloride injection 100 mL,ivgtt,q12 h).The clinical efficacy,bacterial clearance rate and adverse reactions in the two groups were observed.Results:There were no statistically signi?cant differences in the total effective rate and the bacterial clearance rate between the two groups(P>0.05).The incidence of adverse reactions in the vancomycin group was higher than that in the teicoplanin group,and the difference was statistically signi?cant(P<0.05).Conclusion:Teicoplanin has similar efficacy and bacterial clearance rate to vancomycin in the treatment of Gram-positive bacterial infections,but teicoplanin is safer than vancomycin.