肾康注射液治疗糖尿病肾病的疗效及对血清MCP-1和ICAM-1的影响研究

Study on Efficacy of Shenkang Injection in the Treatment of Diabetic Nephropathy and Its Effect on Serum MCP-1 and ICAM-1

目的:研究肾康注射液治疗糖尿病肾病(DN)的疗效及对患者血清单核细胞趋化蛋白(MCP)-1和细胞间黏附分子(ICAM)-1的影响。方法:将我院收治的90例DN患者按随机数字表法分为观察组和对照组,各45例,对照组在常规治疗的基础上应用依那普利(5 mg,qd)治疗,观察组在对照组基础上应用肾康注射液(100 mL加入300 mL5%葡萄糖注射液中,ivgtt,qd)治疗。比较两组临床疗效、治疗前后生化指标[24 h尿蛋白定量(24 hUP)、血α微球蛋白(α-MG)、血肌酐(SCr)]和血清指标(MCP-1、ICAM-1)水平。结果:观察组总有效率高于对照组,差异有统计学意义(P <0.05);治疗后,两组平均24 hUP、α-MG、SCr指标值较治疗前下降,且观察组低于对照组,差异有统计学意义(P <0.05);治疗后,两组平均血清MCP-1、ICAM-1指标值较治疗前均下降,且观察组低于对照组,差异有统计学意义(P <0.05)。结论:肾康注射液治疗DN的疗效显著,能够有效改善患者的肾功能,可能通过调控血清MCP-1和ICAM-1炎性因子来控制病情进展。

Objective:To study the efficacy of shenkang injection in the treatment of diabetic nephropathy(DN)and its effect on serum monocyte chemoattractant protein(MCP)-1 and intercellular adhesion molecule(ICAM)-1.Methods:90 patients with DN admitted to our hospital were randomly divided into an observation group and a control group,45 cases each.The patients in the control group were treated with enalapril(5 mg,qd)on the basis of conventional treatment,and the patients in the observation group were further treated with shenkang injection(100 mL was added to 300 mL 5%glucose injection,ivgtt,qd).The clinical efficacy and the levels of biochemical indexes[24 h urine protein quantitation(24 hUP),bloodαmicroglobulin(α-MG),serun creatinine(SCr)]and serum indexes(MCP-1,ICAM-1)before and after treatment were compared between the two groups.Results:The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The average values of 24 hUP,α-MG and SCr indexes after treatment were lower than those before treatment in the two groups,and the values in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).The average serum values of MCP-1 and ICAM-1 indexes after treatment were lower than those before treatment in the two groups,and the values in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).Conclusion:Shenkang injection has a significant therapeutic effect on DN,which can effectively improve the renal functions of the patients,and may control the progression of the disease by regulating serum MCP-1 and ICAM-1 inflammatory factors.