生长抑素联合泮托拉唑钠治疗重症急性胰腺炎的临床观察分析研究

Clinical Observation and Analysis of Somatostatin Combined with Pantoprazole Sodium in the Treatment of Severe Acute Pancreatitis

目的:分析生长抑素联合泮托拉唑钠治疗重症急性胰腺炎的临床疗效。方法:选取2015年4月—2016年4月我院收治的130例重症急性胰腺炎患者,按随机数字表法分为两组,各65例。对照组采取生长抑素(4 mg溶于500 mL 0.9%氯化钠注射液中,静脉泵入,tid,)治疗,研究组采取生长抑素联合泮托拉唑钠(45 mg溶于150 mL 0.9%氯化钠注射液中,静脉滴入,tid)治疗,比较两组临床疗效、脱离呼吸机时间、血淀粉酶恢复正常时间、疼痛缓解时间和肠道功能恢复时间及治疗前后炎症因子水平。结果 :研究组治疗有效率显著高于对照组,差异有统计学意义(P <0.05);研究组患者脱离呼吸机时间、血淀粉酶恢复正常时间、疼痛缓解时间和肠道功能恢复时间短于对照组,差异有统计学意义(P <0.05);治疗后,研究组肿瘤坏死因子(TNF)-α、超敏C反应蛋白(hs-CRP)、白细胞介素(IL)-8水平低于对照组,差异有统计学意义(P <0.05)。结论 :生长抑素联合泮托拉唑钠治疗重症急性胰腺炎的临床疗效理想,可减低患者体内炎症因子水平,值得临床推广应用。

Objective:To analyze the clinical efficacy of somatostatin combined with pantoprazole sodium in the treatment of severe acute pancreatitis.Methods:130 patients with severe acute pancreatitis admitted to our hospital from April 2015 to April 2016 were selected and randomly divided into two groups,65 cases each.The patients in the control group were treated with somatostatin(4 mg drug was dissolved in 500 mL 0.9%sodium chloride injection,intravenous infusion,tid),and the patients in the study group were treated with somatostatin combined with pantoprazole sodium(45 mg drug was dissolved in 150 mL 0.9%sodium chloride injection,intravenous drip,tid).The clinical efficacy,the time of withdrawing ventilators,the time of blood amylase recovering to normal levels,pain relief time,intestinal function recovery time and the levels of inflammatory factors before and after treatment were compared between the two groups.Results:The effective rate of the treatment in the study group was significantly higher than that in the control group,with statistically significant difference(P<0.05).The time of withdrawing ventilators from patients,the time of blood amylase recovering to normal levels,pain relief time and intestinal function recovery time in the study group were shorter than those in the control group,with statistically significant differences(P<0.05).After treatment,the levels of tumor necrosis factor(TNF)-α,high-sensitivity C-reactive protein(hs-CRP)and interleukin(IL)-8 in the study group were lower than those in the control group,with statistically significant differences(P<0.05).Conclusion:Somatostatin combined with pantoprazole sodium has ideal clinical efficacy in the treatment of severe acute pancreatitis,which can reduce the levels of inflammatory factors in the patients,and is worthy of clinical application.